Frontiers in Neuroscience
2026
Fei Yan, Yansong Li, Ni Xiong et al.
Ciprofol is a novel GABAergic intravenous anesthetic with a rapid onset and favorable safety profile; however, the neural mechanisms underlying the induction and reversal of unconsciousness remain unclear. Electroencephalogram (EEG) microstates provide millisecond-scale markers of large-scale brain network dynamics and may reveal frequency-specific signatures of ciprofol' s effects on...
The International Journal of Neuropsychopharmacology
January 12, 2022
Guang Chen, Li Chen, Yun Zhang et al.
Abstract Background In this post-hoc analysis, data from 2 positive, pivotal, phase 3 trials of esketamine nasal spray (ESK) in treatment-resistant depression (TRD)—short-term study (TRANSFORM-2) and maintenance study (SUSTAIN-1)—were analyzed to evaluate the relationship between dissociation and antidepressant effects of ESK. Methods Analysis by responder status, correlation analysis, and...
International Journal of Neural Systems
June 1, 2021
Yubo Wang, Chenghao Wan, Yun Zhang et al.
Connected consciousness refers to the state when external stimuli can enter into the stream of our consciousness experience. Emerging evidence suggests that although patients may not respond behaviorally to external stimuli during anesthesia, they may be aware of their surroundings. In this work, we investigated whether EEG based brain decoding could be used for detecting connected...
Biomedical Signal Processing and Control
February 1, 2021
Haidong Wang, Yubo Wang, Yun Zhang et al.
Abstract Objective In this study, we comprehensively studied alternations of EEG microstates in resting state, light, and deep level of propofol-induced unconsciousness. We further investigated the feasibility of using microstate features for differentiating different consciousness levels. Methods 60-channel EEG was recorded from 31 male subjects in resting, light, and deep anesthesia states....
JAMA Psychiatry
June 5, 2019
Ella Daly, Madhukar H. Trivedi, Adam Janik et al.
766 citations
Importance: Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established. Objective: To assess the efficacy of esketamine nasal spray plus an oral antidepressant compared with an oral antidepressant plus placebo nasal spray in delaying relapse of depressive symptoms in patients with TRD in stable...
Medicine
June 1, 2019
Jiaming Xue, Yun Zhang, Ying Huang
Abstract: Background: Mindfulness-based interventions (MBIs) have been reported to be efficacious in treating attention deficit hyperactivity disorder (ADHD). However, the value of the control effect of MBIs on ADHD core symptoms remains controversial. To clarify the literature on the control effect of MBIs on the symptoms of ADHD and guide future researches, an effect-size analysis was...
Journal of Clinical Investigation
November 1, 2005
Wen Jiang, Yun Zhang, Lan Xiao et al.
The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory...