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Li Chen

3 papers in the library · 122 citations · publishing 2014-2023

Papers

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Long-Term Safety and Maintenance of Response With Esketamine Nasal Spray in Participants With Treatment-Resistant Depression: Interim Results of the SUSTAIN-3 Study

Neuropsychopharmacology May 12, 2023 Naim Zaki, Li Chen, Rosanne Lane et al. 122 citations

Patients with treatment-resistant depression (TRD) have higher rates of relapse and pronounced decreases in daily functioning and health-related quality of life compared to patients with major depressive disorder who are not treatment-resistant, underscoring the need for treatment choices with sustained efficacy and long-term tolerability. Adults with TRD who participated in ≥1 of 6 phase 3...

The Impact of Gratitude on Connection With Nature: The Mediating Role of Positive Emotions of Self-Transcendence

Frontiers in Psychology June 16, 2022 Li Chen, Jiangxin Liu, Lezhen Fu et al.

Gratitude, as one of the positive emotions associated with self-transcendence, is also a moral and pro-social emotion with a pro-social nature. Therefore, in order to verify whether gratitude has the same effect as pro-social in promoting connection with nature, this study (N = 890) divided subjects into three groups (gratitude, recreation, and control) and used a questionnaire to explore the...

Increasing endocannabinoid levels in the ventral pallidum restore aberrant dopamine neuron activity in the subchronic PCP rodent model of schizophrenia.

The International Journal of Neuropsychopharmacology October 31, 2014 David D Aguilar, Li Chen, Daniel J Lodge

Schizophrenia is a debilitating disorder that affects 1% of the US population. While the exogenous administration of cannabinoids such as tetrahydrocannabinol is reported to exacerbate psychosis in schizophrenia patients, augmenting the levels of endogenous cannabinoids has gained attention as a possible alternative therapy to schizophrenia due to clinical and preclinical observations. Thus,...