Journal of Affective Disorders
October 1, 2025
Xueke Wang, Li Chen, Tingyong Feng
Psychological interventions based on mindfulness and cognition have shown promise for treating ADHD, yet their application in children remains understudied. This study aimed to investigate the effectiveness and sustainability of mindfulness and cognitive strategy interventions in reducing core symptoms of ADHD in children. A randomized controlled trial (RCT) was conducted involving 70 children...
Neuropsychopharmacology
May 12, 2023
Naim Zaki, Li Chen, Rosanne Lane et al.
122 citations
Patients with treatment-resistant depression (TRD) have higher rates of relapse and pronounced decreases in daily functioning and health-related quality of life compared to patients with major depressive disorder who are not treatment-resistant, underscoring the need for treatment choices with sustained efficacy and long-term tolerability. Adults with TRD who participated in ≥1 of 6 phase 3...
Frontiers in Psychology
June 16, 2022
Li Chen, Jiangxin Liu, Lezhen Fu et al.
Gratitude, as one of the positive emotions associated with self-transcendence, is also a moral and pro-social emotion with a pro-social nature. Therefore, in order to verify whether gratitude has the same effect as pro-social in promoting connection with nature, this study (N = 890) divided subjects into three groups (gratitude, recreation, and control) and used a questionnaire to explore the...
The International Journal of Neuropsychopharmacology
January 12, 2022
Guang Chen, Li Chen, Yun Zhang et al.
Abstract Background In this post-hoc analysis, data from 2 positive, pivotal, phase 3 trials of esketamine nasal spray (ESK) in treatment-resistant depression (TRD)—short-term study (TRANSFORM-2) and maintenance study (SUSTAIN-1)—were analyzed to evaluate the relationship between dissociation and antidepressant effects of ESK. Methods Analysis by responder status, correlation analysis, and...
The International Journal of Neuropsychopharmacology
October 31, 2014
David D. Aguilar, Li Chen, Daniel J Lodge
Schizophrenia is a debilitating disorder that affects 1% of the US population. While the exogenous administration of cannabinoids such as tetrahydrocannabinol is reported to exacerbate psychosis in schizophrenia patients, augmenting the levels of endogenous cannabinoids has gained attention as a possible alternative therapy to schizophrenia due to clinical and preclinical observations. Thus,...