Ciprofol is a novel GABAergic intravenous anesthetic with a rapid onset and favorable safety profile; however, the neural mechanisms underlying the induction and reversal of unconsciousness remain unclear. Electroencephalogram (EEG) microstates provide millisecond-scale markers of large-scale brain network dynamics and may reveal frequency-specific signatures of ciprofol' s effects on...
Abstract Objective In this study, we comprehensively studied alternations of EEG microstates in resting state, light, and deep level of propofol-induced unconsciousness. We further investigated the feasibility of using microstate features for differentiating different consciousness levels. Methods 60-channel EEG was recorded from 31 male subjects in resting, light, and deep anesthesia states....