Journal of the American Academy of Child & Adolescent Psychiatry
March 17, 2026
Yunjia Liu, Qiang Wang
Adolescent major depressive disorder (MDD) is a leading cause of disability worldwide and a major, modifiable risk factor for suicide, which remains the second leading cause of death in this age group.1 For 30% to 50% of patients who fail to achieve remission despite multiple treatment steps, the clinical and psychosocial consequences are substantial.2 Although selective serotonin-reuptake...
European Journal of Pharmacology
March 28, 2023
Ailing Huang, Yang Chen, Shaoshuang Wang et al.
Post-stroke anxiety (PSA) is a kind of affective disorder occurring after a stroke, with anxiety as the primary clinical manifestation. PSA's mechanism is unclear, and there are few prevention and treatment measures. Our previous study found that HDAC3 could activate NF-κB signaling through mediated p65 deacetylation, which further influenced microglia activation. That implies HDAC3 may be the...
International Journal of Neural Systems
June 1, 2021
Yubo Wang, Chenghao Wan, Yun Zhang et al.
Connected consciousness refers to the state when external stimuli can enter into the stream of our consciousness experience. Emerging evidence suggests that although patients may not respond behaviorally to external stimuli during anesthesia, they may be aware of their surroundings. In this work, we investigated whether EEG based brain decoding could be used for detecting connected...
Biomedical Signal Processing and Control
February 1, 2021
Haidong Wang, Yubo Wang, Yun Zhang et al.
Abstract Objective In this study, we comprehensively studied alternations of EEG microstates in resting state, light, and deep level of propofol-induced unconsciousness. We further investigated the feasibility of using microstate features for differentiating different consciousness levels. Methods 60-channel EEG was recorded from 31 male subjects in resting, light, and deep anesthesia states....
International Journal of Neural Systems
January 23, 2020
Wen Shi, Yamin Li, Zhian Liu et al.
Dynamically assessing the level of consciousness is still challenging during anesthesia. With the help of Electroencephalography (EEG), the human brain electric activity can be noninvasively measured at high temporal resolution. Several typical quasi-stable states are introduced to represent the oscillation of the global scalp electric field. These so-called microstates reflect spatiotemporal...
International Journal of Molecular Sciences
January 18, 2017
Qiang Wang, Qinghui Wu, Junpeng Wang et al.
The novel synthetic psychoactive ketamine analog methoxetamine is reportedly being used for recreational purposes. As ketamine use can result in urinary dysfunction, we conducted the present study to investigate how methoxetamine affects the bladder. A cystometry investigation showed that female Sprague-Dawley rats experienced increased micturition frequency bladder dysfunction after receiving...