COMT Val158Met moderation of cannabis‐induced psychosis: a momentary assessment study of ‘switching on’ hallucinations in the flow of daily life
Cécile Henquet, Araceli Rosa, Philippe Delespaul, Sergi Papiol, Lourdes Fañanás, Jim van Os, Inez Myin-Germeys
Acta Psychiatrica Scandinavica September 19, 2008 DOI: 10.1111/j.1600-0447.2008.01265.x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Momentary assessment study (experience sampling) Peer reviewed |
|---|---|
| Sample size | 56 |
| Population | Patients with a psychotic disorder (n=31) and healthy controls (n=25) |
| Intervention | Cannabis |
| Topics | Cannabis |
| Citations | 117 |
| Key points | Carriers of the COMT Val158Met Val allele, but not those with the Met/Met genotype, showed increased hallucinations after cannabis exposure, conditional on prior psychometric evidence of psychosis liability. The authors conclude that COMT Val158Met genotype moderates the association between cannabis and psychotic phenomena in daily life among people with psychometric psychosis liability. |
Abstract
Objective: A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted.
Method: The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (n = 31) and healthy controls (n = 25).
Results: Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability.
Conclusion: The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cited by 18
- Gone to Pot – A Review of the Association between Cannabis and Psychosis Frontiers in Psychiatry May 22, 2014
- Cannabis use and cognition in schizophrenia Frontiers in Human Neuroscience 2009
- Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use Brain and Behavior October 6, 2017
- Cannabis and Psychosis: A Review of the Risk Factors Involved American Journal of Plant Sciences 2020
- Psychotropic Effects of Cannabis Plant-Based Therapeutics, Volume 1 2023
and 13 more in the library