Frontiers in Psychiatry
June 20, 2023
Johannes T. Reckweg, Cees van Leeuwen, Cécile Henquet et al.
86 citations
Background Treatment-resistant depression (TRD) is a substantial public health burden, but current treatments have limited effectiveness. The aim was to investigate the safety and potential antidepressant effects of the serotonergic psychedelic drug 5-MeO-DMT in a vaporized formulation (GH001) in adult patients with TRD. Methods The Phase 1 part ( n = 8) of the trial investigated two single...
European Psychiatry
June 1, 2022
Johannes T. Reckweg, Natasha L. Mason, Cees van Leeuwen et al.
3 citations
Introduction 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes. Objectives In preparation for a study in patients with depression, the present study GH001-HV-101 aimed to assess the impact of four different dose levels...
Frontiers in Human Neuroscience
May 11, 2022
Irem Duman, Isabell Sophia Ehmann, Alicia Ronnie Gonsalves et al.
In the cognitive neuroscience of consciousness, participants have commonly been instructed to report their conscious content. This, it was claimed, risks confounding the neural correlates of consciousness (NCC) with their preconditions, i.e., allocation of attention, and consequences, i.e., metacognitive reflection. Recently, the field has therefore been shifting towards no-report paradigms....
Frontiers in Pharmacology
2021
Johannes T. Reckweg, Natasha L. Mason, Cees van Leeuwen et al.
58 citations
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies for other tryptamines have suggested beneficial effects on mental health outcomes. In preparation for a study in patients with depression, the present study GH001-HV-101 aimed to assess the impact of four different dose levels of a novel vaporized...
Neuroscience of Consciousness
2018
Tomer Fekete, Sander van de Cruys, Vebjørn Ekroll et al.
40 citations
A recently proposed model of sensory processing suggests that perceptual experience is updated in discrete steps. We show that the data advanced to support discrete perception are in fact compatible with a continuous account of perception. Physiological and psychophysical constraints, moreover, as well as our awake-primate imaging data, imply that human neuronal networks cannot support discrete...
Frontiers in Psychology
October 4, 2016
Tomer Fekete, Cees van Leeuwen, Shimon Edelman
A computational theory of consciousness should include a quantitative measure of consciousness, or MoC, that (i) would reveal to what extent a given system is conscious, (ii) would make it possible to compare not only different systems, but also the same system at different times, and (iii) would be graded, because so is consciousness. However, unless its design is properly constrained, such an...
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
May 5, 2014
Antonino Raffone, Narayanan Srinivasan, Cees van Leeuwen
85 citations
Despite the acknowledged relationship between consciousness and attention, theories of the two have mostly been developed separately. Moreover, these theories have independently attempted to explain phenomena in which both are likely to interact, such as the attentional blink (AB) and working memory (WM) consolidation. Here, we make an effort to bridge the gap between, on the one hand, a theory...