In a small clinical trial with 16 adults suffering from treatment-resistant depression, an inhaled form of the psychedelic drug 5-MeO-DMT (GH001) was well tolerated and produced rapid antidepressant effects. An individualized dosing regimen of up to three increasing doses within a single day led to 87.5% of patients achieving remission (a depression score of 10 or less on the MADRS scale) by day 7, compared to 50% and 25% for single doses of 12 mg and 18 mg, respectively. Remission occurred as early as two hours after dosing for some patients. The findings suggest that individualized dosing may be more effective than a single dose.
Auditory verbal hallucinations occur along a continuum from the general population to patients with psychosis, yet how sensory feedback processing and attention control interact along this continuum is unclear. By manipulating self-voice quality (from neutral to angry) and measuring brain activity with electroencephalography, the study found that hallucination proneness (HP) modulated the N100 and P200 suppression effects regardless of voice quality. Individuals with high HP showed an increased N100 response to self-generated voices and an increased P200 response to externally-generated voices, suggesting heightened error awareness and attention allocation during self-voice production due to altered sensory feedback processing and attentional control. These findings indicate that altered sensory feedback processing in self-voice production is a fundamental characteristic of the HP continuum, independent of clinical status.