Alpha psychiatry
August 2026
Lei Yang, Qiuyu Zhang, Ying Zhang et al.
Ketamine may have antidepressant and anti-suicidal effects. However, the mechanism underlying ketamine-mediated improvement in cognitive impairment in patients with depression remains unclear. To improve patient cognition in depression using molecular docking and network pharmacology, we examined ketamine's key targets and identified its molecular mechanisms. To gain target information about...
Neurotherapeutics
November 11, 2025
Zhaojuan Ke, Ying Zhang, Xin Jiang et al.
Ketamine exhibits superior efficacy compared to conventional antidepressants, yet its clinical application remains limited by dose-dependent side effects. Ascorbic acid (AA) augments ketamine's antidepressant-like effects, suggesting that AA co-administration with subtherapeutic ketamine doses may achieve optimal efficacy while improving safety. Since AA itself lacks independently clinical...
Translational Psychiatry
June 16, 2025
Ying Zhang, Lei Yang, Qiuyu Zhang et al.
6 citations
Psilocybin is among the most extensively studied psychedelics, with previous research suggesting its potential therapeutic role in suicide prevention. However, the precise mechanisms through which psilocybin may aid in suicide prevention remain unclear. This study thus employed network pharmacology and molecular docking tools to explore the mechanisms by which psilocybin may contribute to...
Journal of Affective Disorders
June 15, 2025
Guangzheng Tang, Bijun Chen, Manhua Wu et al.
Mindfulness-based cognitive therapy (MBCT) has emerged as a promising intervention for generalized anxiety disorder (GAD). This study evaluated MBCT's effectiveness for GAD and examined whether childhood maltreatment moderates its impact. Individuals with GAD were randomized to receive one of two 8-week interventions, either MBCT in-person or psychoeducation on-line (n = 27 per group). At...
Neuropsychiatric Disease and Treatment
2025
Ying Zhang, Zhaojuan Ke, Jie Luo et al.
3 citations
Major depressive disorder (MDD) has a high incidence and high risk of suicide. Electroconvulsive therapy (ECT) is a highly effective and rapid physical therapy for MDD but limited by adverse effects. Ketamine/esketamine are new emerging rapid antidepressants, which can synergize the efficacy and safety of ECT but come with other side effects. Binaural beat music (BBM) is a non-invasive...
Neuropsychiatric Disease and Treatment
2025
Zhaojuan Ke, Ying Zhang, Binyang Cai et al.
1 citation
Pregnancy leads to vulnerabilities and susceptibilities to mental disorders. Miscarriage, as an adverse pregnancy outcome, and following curettage for treatment, add the risks of further psychiatric disorders, including depression, anxiety, insomnia, etc., and current approaches to prevention are unsatisfactory. Ketamine and its S-enantiomer esketamine can prevent postpartum depression, and...
Journal of Clinical Hypertension
May 31, 2023
Haifei Shen, Ri Zhang, Xiujie Zhang et al.
7 citations
To explore the moderating effect of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension and provide a foundation for the development of more effective mindfulness intervention strategies. A total of 109 middle-aged and elderly female patients with hypertension participated in this cross-sectional study from April...
Research Square
November 22, 2022
Haifei Shen, Ri Zhang, Xiujie Zhang et al.
preprint
Abstract Purpose: To explore the moderation of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension, and provide foundation for the development of more effective mindfulness intervention strategies. Methods: A total of 109 middle-aged and elderly female patients with hypertension were participated in this...