Ascorbic acid enhances antidepressant-like efficacy of esketamine: Hippocampal TARP-γ8-containing AMPA receptors mediate synaptic modulation.
Neurotherapeutics November 11, 2025 DOI: 10.1016/j.neurot.2025.e00786 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preclinical animal study Peer reviewed |
|---|---|
| Population | Rodents (preclinical animal model) |
| Interventions | Esketamine Ascorbic acid |
| Topics | Esketamine |
| Key points | Ascorbic acid enhanced the antidepressant-like efficacy of esketamine in rodents, an effect the authors link to modulation of hippocampal synapses involving TARP-γ8-containing AMPA receptors. The authors propose that ascorbic acid may serve as an adjunct to strengthen esketamine's antidepressant-like actions via AMPA-receptor-mediated synaptic mechanisms. |
Abstract
Ascorbic acid enhances antidepressant-like efficacy of esketamine: Hippocampal TARP-γ8-containing AMPA receptors mediate synaptic modulation.