Background: Depression is a common complication of Parkinson disease (PD). This study investigated whether a single dose of esketamine could alleviate depressive symptoms in an MPTP mouse model by activating G protein-coupled receptor 109 A (GPR109A) and reducing neuroinflammation. Methods: Adult male C57BL/6 J mice (8 weeks, 25–30 g) were allocated into three groups: saline,...
iScienceOctober 20, 2023Jie-Ying Chen, Ke Wu, Miao-Miao Guo et al.
Depression is a global disease with a high prevalence. Here, we examine the role of the circuit from prelimbic mPFC (PrL) to the anterior ventral bed nucleus of the stria terminalis (avBNST) in depression-like mice through behavioral tests, immunofluorescence, chemogenetics, optogenetics, pharmacology, and fiber photometry. Mice exposed to chronic restraint stress with individual housing...
To explore the moderating effect of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension and provide a foundation for the development of more effective mindfulness intervention strategies. A total of 109 middle-aged and elderly female patients with hypertension participated in this cross-sectional study from April...
Research SquareNovember 22, 2022Haifei Shen, Ri Zhang, Xiujie Zhang et al.
preprint
Abstract Purpose: To explore the moderation of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension, and provide foundation for the development of more effective mindfulness intervention strategies. Methods: A total of 109 middle-aged and elderly female patients with hypertension were participated in this...