Mindfulness
August 21, 2026
Qing Fan, Wei Zhang, Yilin Liu et al.
Abstract: Objectives: Diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes, with neuropathic pain and sensory abnormalities severely affecting patients’ quality of life. Current pharmacological treatments have limitations including insufficient efficacy and adverse reactions. Mindfulness-based interventions (MBIs) show potential in chronic pain management, yet their...
Cell Biology and Toxicology
January 30, 2026
Jia-Yi Wei, Peng Lv, Jiayu Zhang et al.
Repeated exposure to ketamine leads to mental behavioral disorders and cognitive deficits in mice. As a neurotransmitter receptor, dopamine receptor 1 (DRD1) is involved in mental regulation and memory formation. However, the role of DRD1 in ketamine's behavioral disorder and neurotoxicity remains unclear. We found that seven-day ketamine exposure induced anxiety-like, depressive-like behavior...
Cell Biology and Toxicology
November 25, 2025
Peng Lv, Jiayu Zhang, Jia-Yi Wei et al.
Psychotic disorders frequently result from repeated ketamine exposure, yet the underlying mechanisms remain elusive. We propose that repeated exposure to ketamine may induce psychotic-like behaviors via DRD1-mediated nuclear signaling pathways. Our investigation focused on phosphorylated DARPP-32 at Thr34, Thr75, and Ser97, alongside transcriptome profiling in both cell and mouse models. We...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
June 1, 2024
Xue Wu, Gehua Wen, Lei Yan et al.
11 citations
Ketamine, as a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, was originally used in general anesthesia. Epidemiological data show that ketamine has become one of the most commonly abused drugs in China. Ketamine administration might cause cognitive impairment; however, its molecular mechanism remains unclear. The glymphatic system is a lymphoid system that plays a key...
Journal of Clinical Hypertension
May 31, 2023
Haifei Shen, Ri Zhang, Xiujie Zhang et al.
7 citations
To explore the moderating effect of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension and provide a foundation for the development of more effective mindfulness intervention strategies. A total of 109 middle-aged and elderly female patients with hypertension participated in this cross-sectional study from April...
Research Square
November 22, 2022
Haifei Shen, Ri Zhang, Xiujie Zhang et al.
preprint
Abstract Purpose: To explore the moderation of mindfulness on the relationship between anxiety and somatization symptoms in middle-aged and elderly female patients with hypertension, and provide foundation for the development of more effective mindfulness intervention strategies. Methods: A total of 109 middle-aged and elderly female patients with hypertension were participated in this...
Neurotoxicology and Teratology
February 21, 2022
Xiaojiaoyang Li, Juanhan Yu, Xue Wu et al.
The abnormal expression of the dopamine D1 receptor (DRD1) may be associated with schizophrenia. MicroRNAs (miRNAs) can post-transcriptionally regulate DRD1 expression. Here, we established a ketamine-induced schizophrenia-like behavior mouse model and investigated the changes in miR-15a-3p, miR-15b-3p, miR-16-1-3p, and DRD1 in response to ketamine. Administration of high-dose ketamine for...