Ketamine may have antidepressant and anti-suicidal effects. However, the mechanism underlying ketamine-mediated improvement in cognitive impairment in patients with depression remains unclear. To improve patient cognition in depression using molecular docking and network pharmacology, we examined ketamine's key targets and identified its molecular mechanisms. To gain target information about...
Understanding the physiological changes induced by ketamine in mood disorders, while reducing its side effects, is likely to contribute to a more comprehensive understanding of the physiology underlying mood disorders, as well as to the development of faster-acting and more efficacious antidepressant treatments. An extensive review of the literature on ketamine and the pathophysiology of...
Alpha psychiatryApril 21, 2026Georgios D Floros, Petros Petrou, Ioanna Mylona
Despite ongoing discussions regarding the connection between overt psychosis and the impairment of visual function, the discourse primarily centers on the potential neurobiological association between major psychotic disorders and congenital blindness. Specific neurological lesions are associated with psychotic symptoms, including visual hallucinations. Defining and assessing psychotic-like...
This systematic review aimed to investigate the effectiveness of mindfulness-based interventions (MBIs) in treating depression, enhancing interoceptive awareness (IA), and whether IA mediates this relationship. In August 2024, a comprehensive literature search was conducted in web-based medical and psychological databases, including PsycINFO, MEDLINE, and Scopus, following the Preferred...
To explore the effect of self-help mindfulness-based stress reduction exercise therapeutics (MBSRET) on the psychological status and sleep quality of medical staff. A total of 85 Hubei medical staff were randomly divided into an intervention group (n = 43) and a control group (n = 42). The intervention group received MBSRET for 8 weeks and the control group received routine care. Psychological...
Given their great importance, as one of the most prescribed types of therapeutic drugs worldwide, we have analyzed the role of serendipity in the discovery of new antidepressants, ranging from selective serotonin reuptake inhibitors to more contemporary developments. We carried out a historical analysis of the discovery of new antidepressants, resorting to the original articles published on...
Alpha psychiatrySeptember 1, 2024Murad Atmaca, Muhammed Fatih Tabara, Mehmet Gürkan Gürok1 citation
Studies evaluating the efficacy of detached mindfulness (DM) as a standalone intervention for patients with panic disorder are lacking in the literature. In this context, the aim of this open study was to evaluate the efficacy of DM in patients with panic disorder. The study was conducted in 11 patients (7 females and 4 males). The DM therapy process was applied to the patients. The clinical...
Treatment-resistant depression (TRD) affects around 20-30% of people with major depressive disorder. In 2019, esketamine nasal spray was approved for TRD by both the US Food and Drug Administration and the European Medicines Agency. While its clinical efficacy and safety are proven, the mechanisms underlying its antidepressant effect remain unclear. The use of metabolomics may allow...
The aim was to analyze the effects of nurse-led mindfulness-based cognitive therapy (MBCT) in hospitalized elderly suicide survivors. The data of middle-aged and elderly suicide survivors in the medical system and nursing records of our hospital from January 2018 to August 2023 were retrospectively collected. The patients were divided into conventional group and MBCT group according to whether...
Alpha psychiatryMarch 1, 2024Anna Famuła, Jakub Radoszewski, Tomasz Czerwiec et al.8 citations
Substance use disorder (SUD) continues to pose a significant global health challenge, necessitating innovative and effective therapeutic interventions. Ketamine, traditionally recognized for its anesthetic properties, has emerged as a novel and promising avenue for the treatment of SUD. This narrative review critically examines the current body of literature surrounding the use of ketamine in...
This study aims to assess the efficacy of mindfulness-based cognitive therapy (MBCT) in alleviating depression in older adults. A comprehensive search was conducted in 4 electronic databases and 1 registered database from inception up to July 2021 to identify relevant trials. The meta-analysis employed Hedge's g, along with its 95% CI, and associated z and P-values for the included studies,...
Alpha psychiatry2024Murad Atmaca, Muhammed Fatih Tabara, Mehmet Gürkan Gürok3 citations
The objective of this study was to evaluate the effectiveness of detached mindfulness (DM) in patients with obsessive-compulsive disorder (OCD). Seventeen adult patients with OCD, who were receiving psychotropic medication, were included in the study. M.A., a qualified metacognitive therapist at the Metacognitive Therapy Institute in Manchester, conducted DM therapy. The Yale-Brown Obsession...
The clinical heterogeneity of dissociation constitutes a challenge to the culture-sensitive clinician. Variability in experiencing dissociation, the interplay between acute and chronic conditions, and the predominance of a nosologically interface-type of clinical surface conceal core dissociative symptoms. While the latter (amnesia, depersonalization, derealization, identity confusion, and...