Rui Yuan

2 papers in the library · publishing 2019

Papers

Effect of ketamine combined with DHA on lipopolysaccharide-induced depression-like behavior in rats.

International Immunopharmacology August 1, 2019 Daiyue Chang, Jinghua Zhao, Xintong Zhang et al.

Ketamine combined with docosahexaenoic acid (DHA), an unsaturated fatty acid, reversed depression-like behaviors in rats exposed to lipopolysaccharide, an inflammatory trigger. The combination reduced immobility time in forced swimming and tail suspension tests and increased sucrose preference more effectively than either agent alone. It also reversed nerve damage, reduced inflammatory cytokines IL-1, IL-6, and TNF-α in the hippocampus and PC12 cells, increased brain-derived neurotrophic factor (BDNF), inhibited PP65 nuclear translocation, and suppressed NF-κB expression while increasing P-CREB and BDNF. The findings suggest that combining ketamine with DHA may offer a more effective treatment for inflammation-driven depression by inhibiting inflammatory pathways.

DOI: 10.1016/j.intimp.2019.105788 Biology Medicine

Optogenetic stimulation of anterior insular cortex neurons reveals causal mechanisms underlying suppression of the default mode network by the salience network

Vinod Menon, Domenic Cerri, Byeongwook Lee et al. preprint

Stimulating neurons in the anterior insular cortex of rats suppresses activity in the default mode network and reduces functional connectivity between the salience network and default mode network, as well as within the default mode network itself. The findings demonstrate a causal role for anterior insular cortex neurons in dynamically suppressing and decoupling the default mode network, revealing previously unknown features of rodent brain network organization and advancing understanding of cross-network interactions and brain network switching.

DOI: 10.1101/2022.06.06.495040