Background: Brainstem reticular formation (BRF) is crucially involved in regulating arousal, making it a potential target for reversing general anesthesia. The transnasal approach provides a minimally invasive access to the ventral brainstem. However, whether this approach can effectively modulate arousal remains unknown. Objective: To evaluate the efficacy of transnasal BRF electrical...
medRxivJuly 29, 2025Yuwen He, Shan Lei, Wangli Si et al.
preprint
Abstract Background Somatic awareness is a fundamental practice for novice mindfulness practitioners. It has been proposed that mindfulness meditation training (MMT) enhances brain function through somatic awareness in both non-clinical and clinical populations. However, the neural signatures underlying this mechanism remain poorly understood. Methods In our study, we conducted mindfulness...
Recent studies have demonstrated resting-state abnormalities in midline regions in vegetative state/unresponsive wakefulness syndrome and minimally conscious state patients. However, the functional implications of these resting-state abnormalities remain unclear. Recent findings in healthy subjects have revealed a close overlap between the neural substrate of self-referential processing and the...