Pharmacology, biochemistry, and behavior
July 26, 2026
Peng Zhang, Mengyu Wu, Keke Zhang et al.
Esketamine has been approved for the treatment of treatment-resistant depression. However, there is an unmet clinical need to extend the duration of esketamine's action to reduce the high recurrence rate after drug withdrawal and the potential side effects of repeated esketamine use. Here, we found that increasing extracellular signal-regulated kinase (ERK) activity by pharmacologically...
arXiv Preprint Archive
October 18, 2023
Bohao Tian, Shijun Zhang, Sirui Chen et al.
Flow, an optimal mental state merging action and awareness, significantly impacts our emotion, performance, and well-being. However, capturing its swift fluctuations on a fine timescale is challenging due to the sparsity of the existing flow detecting tools. Here we present a fine fingertip force control (F3C) task to induce flow, wherein the task challenge is set at a compatible level with...
Pharmacology, biochemistry, and behavior
September 1, 2023
Yixue Qin, Haoxuan Li, Yuqi Zhang et al.
6 citations
Ketamine has been increasingly used as a rapid-onset antidepressant in specific clinical settings. However, as a psychedelic reagent, the potential of physical and psychological dependence limits its clinical use. Here, we added retigabine, a KCNQ channel opener, as an adjunctive treatment to observe its effect on ketamine's antidepressant property in a forced swim test in both male and female...
Neurobiology of Stress
August 1, 2023
Min Cai, Yingbo Zhu, M. R. Shanley et al.
Repeated, long-term (weeks to months) exposure to standard antidepressant medications is required to achieve treatment efficacy. In contrast, acute ketamine quickly improves mood for an extended time. Recent work implicates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are involved in mediating ketamine's antidepressant effects. In this study, we directly targeted HCN...
Frontiers in Neuroscience
July 31, 2019
Yujiao Zhang, Zhenyi Li, J. Zhang et al.
13 citations
Near-death experiences (NDE) are episodes of enhanced perception with impending death, which have been associated with increased high-frequency (13–100 Hz) synchronization of neuronal activity, which is implicated in cognitive processes like perception, attention and memory. To test whether the NDE-associated high-frequency oscillations surge is related to cardiac arrest, recordings were made...