Revista CPAQV - Centro de Pesquisas Avançadas em Qualidade de Vida
October 4, 2024
Claudio Mateus Gnoatto, Keyla Liana Bezerra Machado, Rian Ricardo Henrique da Silva et al.
Introdução: O Transtorno Depressivo Maior (TDM) é altamente prevalente e incapacitante, ocupando um alto ônus globalmente. No Brasil, afeta 15,5% da população. A fisiopatologia da depressão envolve teorias, incluindo a monoaminérgica e a dos receptores monoaminérgicos, embora nenhuma seja conclusiva. Tratamentos farmacológicos baseiam-se na teoria monoaminérgica, apesar de suas limitações. Além...
Archives of Toxicology
August 1, 2015
Ana Margarida Araújo, Félix Carvalho, Maria de Lourdes Bastos et al.
290 citations
In the area of psychotropic drugs, tryptamines are known to be a broad class of classical or serotonergic hallucinogens. These drugs are capable of producing profound changes in sensory perception, mood and thought in humans and act primarily as agonists of the 5-HT2A receptor. Well-known tryptamines such as psilocybin contained in Aztec sacred mushrooms and N,N-dimethyltryptamine (DMT),...
Forensic Science International
September 1, 2014
Fernando Xavier Moreira, Félix Carvalho, Maria de Lourdes Bastos et al.
13 citations
Lately, the hallucinogenic plant Salvia divinorum has been considered a popular recreational product among adolescents, being legally sold in several countries in "smartshops" and in internet websites. Sellers frequently omit the safety information about the plant, encouraging its use for recreational purposes, without providing adequate qualitative and quantitative details. The principal...
British Journal of Pharmacology
April 21, 2011
Daniel José Barbosa, João Paulo Capela, Jorge M.A. Oliveira et al.
60 citations
BACKGROUND AND PURPOSE: 3,4-Methylenedioxymethamphetamine (MDMA or 'Ecstasy') is a worldwide major drug of abuse known to elicit neurotoxic effects. The mechanisms underlying the neurotoxic effects of MDMA are not clear at present, but the metabolism of dopamine and 5-HT by monoamine oxidase (MAO), as well as the hepatic biotransformation of MDMA into pro-oxidant reactive metabolites is thought...
JOURNAL OF HEALTH SCIENCE
2007
Carla Macedo, Paula S. Branco, Luı́sa M. Ferreira et al.
36 citations
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a widely abused, psychoactive recreational drug. There are growing evidences that the MDMA neurotoxic profile may be highly dependent on its hepatic metabolism. MDMA metabolism leads to the production of highly reactive derivates, namely catechols, catechol thioethers, and quinones. In this study the electrochemical oxidation-reduction...
Toxicology
January 5, 2005
Helena Carmo, Jan G Hengstler, Douwe De Boer et al.
85 citations
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive designer drug of abuse that is sold under the street names "Venus", "Bromo", "Erox", "XTC" or "Nexus". Concern has been raised because only little is known about its toxicity and metabolism in humans. In the present study we incubated 2C-B with human, monkey, dog, rabbit, rat and mouse hepatocytes to identify the metabolites formed...
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
November 25, 2004
Helena Carmo, Douwe De Boer, Fernando Remião et al.
32 citations
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS...
Chemical Research in Toxicology
April 27, 2004
Márcia Carvalho, Fernando Remião, Nuno Milhazes et al.
77 citations
Cardiovascular complications associated with 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) abuse have increasingly been reported. The indirect effect of MDMA mediated by a sustained high level of circulating biogenic amines may contribute to the cardiotoxic effects, but other factors, like the direct toxic effects of MDMA and its metabolites in cardiac cells, remain to be investigated....