Metabolism of the designer drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in mice, after acute administration.
Helena Carmo, Douwe De Boer, Fernando Remião, Félix Carvalho, Lesseps A Dos Reys, Maria de Lourdes Bastos
Journal of Chromatography B November 25, 2004 DOI: 10.1016/j.jchromb.2004.08.026 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Mice |
| Intervention | 2C-B |
| Keywords | Drug metabolism Forensic toxicology Psychoactive drugs Animal studies |
| Citations | 32 |
| Key points | Unchanged 2C-B and several metabolites were identified in mouse urine by GC/MS. |
Abstract
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is a psychoactive drug of abuse often sold under the general street name "Ecstasy". Recent reports on the abuse of 2C-B and analogues denote the lack of knowledge on this drug metabolism. In the present study, we investigated the metabolic profile of 2C-B in the mouse and found unchanged 2C-B and several metabolites, which could be identified by GC/MS in the mice urine. The identification of 2C-B metabolites may give important clues for the biological and toxicological effects of this drug of abuse and provides new important data for forensic analysis on samples taken from 2C-B abusers.
Citations in the library
Cited by 8
- Metabolism of designer drugs of abuse: an updated review. Current Drug Metabolism June 1, 2010
- Acute Pharmacological Effects of 2C-B in Humans: An Observational Study Frontiers in Pharmacology March 13, 2018
- Identification of monoamine oxidase and cytochrome P450 isoenzymes involved in the deamination of phenethylamine-derived designer drugs (2C-series). Biochemical Pharmacology January 15, 2007
- Behavioral, neurochemical and pharmaco-EEG profiles of the psychedelic drug 4-bromo-2,5-dimethoxyphenethylamine (2C-B) in rats. Psychopharmacology 2013
- Acute Effects of the Novel Psychoactive Drug 2C-B on Emotions BioMed Research International 2015
and 3 more in the library
Cites 6
- A new trend in drugs-of-abuse; the 2C-series of phenethylamine designer drugs. Pharmacy world & science : PWS April 1, 2004
- 2C-B: a new psychoactive phenylethylamine recently discovered in Ecstasy tablets sold on the Swiss black market. Journal of Analytical Toxicology September 1, 1998
- 3,4,5-Trimethoxyphenylacetaldehyde, an Intermediate Metabolite of Mescaline, Is a Substrate for Microsomal Aldehyde Oxygenase in the Mouse Liver. Biological and Pharmaceutical Bulletin 1995
- Interactions of amphetamine analogs with human liver CYP2D6. Biochemical Pharmacology June 1, 1997
- A behavioral comparison of Nexus, cathinone, BDB, and MDA. Pharmacology, Biochemistry, and Behavior 1995
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