Neurobiological Models of Self-Disorders in Early Schizophrenia.
Aaron Mishara, Ilaria Bonoldi, P Allen, G Rutigliano, J Perez, Paolo Fusar‐poli, P McGuire
Schizophrenia Bulletin July 2016 DOI: 10.1093/schbul/sbv123 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Philosophy of mind |
| Keywords | Bayesian modeling Gruhle Heidelberg mescaline study Mayer-gross Aberrant salience Neuroimaging Prodromal Psychosis Schizophrenia Self-disorders |
| Key findings | The authors argue that self-disorders, alterations of the first-person perspective associated with schizophrenia particularly in early phases, have unknown neurobiological underpinnings, which hinders their integration into contemporary models of psychosis. The review traces a historical interconnection between neuroscientific models and the origin of the psychopathological concept of self-disorders, then discusses recent neurobiological models in relation to schizophrenia onset. |
Abstract
Self-disorders (SDs) (from the German Ichstörungen) are alterations of the first-person perspective, long associated with schizophrenia, particularly in early phases. Although psychopathological features of SDs continue to be studied, their neurobiological underpinnings are unknown. This makes it difficult to integrate SDs into contemporary models of psychosis. The present review aims to address this issue, starting from an historical excursus revealing an interconnection between neuroscientific models and the origin of the psychopathological concept of SDs. Subsequently, the more recent neurobiological models related to SDs are discussed, particularly with respect to the onset of schizophrenia.
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| Body Consciousness: A Philosophy of Mindfulness and Somaesthetics | 2008 | Review article | |
| Phenomenology, Structure, and Dynamic of Psychedelic States | 2016 | Review | |
| Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates. | 2018 | Review | |
| The lived experience of psychosis: a bottom-up review co-written by experts by experience and academics. Individuals with lived experience of psychosis, family members, and carers | 2022 | Co-written bottom-up review | |
| From autopoiesis to neurophenomenology: Francisco Varela's exploration of the biophysics of being. | 2003 | Review |
Citations in the library
Cited by 17
- Looking for the Self: Phenomenology, Neurophysiology and Philosophical Significance of Drug-induced Ego Dissolution Frontiers in Human Neuroscience May 23, 2017
- The neurophenomenology of early psychosis: An integrative empirical study. Consciousness and Cognition November 1, 2019
- Hallucinations Beyond Voices: A Conceptual Review of the Phenomenology of Altered Perception in Psychosis. Schizophrenia Bulletin February 1, 2019
- Thought insertion as a self-disturbance: An integration of predictive coding and phenomenological approaches Frontiers in Human Neuroscience December 22, 2016
- Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders Scientific Reports August 15, 2017
and 12 more in the library
Cites 7
- From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis. Schizophrenia Research November 1, 2005
- Self‐experience in the early phases of schizophrenia: 5‐year follow‐up of the Copenhagen Prodromal Study World Psychiatry October 1, 2011
- What are the neurocognitive correlates of basic self-disturbance in schizophrenia?: Integrating phenomenology and neurocognition. Part 1 (Source monitoring deficits). Schizophrenia Research January 2014
- What are the neurocognitive correlates of basic self-disturbance in schizophrenia? Integrating phenomenology and neurocognition: Part 2 (aberrant salience). Schizophrenia Research January 2014
- Self-disorders and schizophrenia: a phenomenological reappraisal of poor insight and noncompliance. Schizophrenia Bulletin June 24, 2013
and 2 more in the library