Hongyu Wu

Structural basis of psychedelic LSD recognition at dopamine D1 receptor.

Neuron October 9, 2024 Luyu Fan, Youwen Zhuang, Hongyu Wu et al. 6 citations

Understanding the kinetics of LSD in receptors and subsequent induced signaling is crucial for comprehending both the psychoactive and therapeutic effects of LSD. Despite extensive research on LSD's interactions with serotonin 2A and 2B receptors, its behavior on other targets, including dopamine receptors, has remained elusive. Here, we present cryo-EM structures of LSD/PF6142-bound dopamine...