Virtual reality (VR) mindfulness meditation has emerged as a prominent emotion regulation strategy in recent years. Current research often seeks to enhance meditation effectiveness through biofeedback and overlooks the trajectory of emotional changes and the changing needs during regulation. In this study, we propose an electroencephalography (EEG)–based positive feedback mechanism for VR...
Non-suicidal self-injury (NSSI) poses a significant challenge to the health and well-being of children and adolescents, with prior studies suggesting a strong association with experiences of school bullying. While mindfulness has been identified as a protective factor against NSSI, its mediating role in the relationship between school bullying and NSSI remains insufficiently investigated. Using...
In recent years, mindfulness meditation has become increasingly popular as a way to relieve negative emotions. Although many studies have shown the advantages of the most immersive virtual reality (VR) technologies to support mindfulness meditation, few have summarized a standardized process for developing a VR tool to aid mindfulness meditation. We propose an interaction design model for VR...
Ketamine, an FDA-approved N-methyl-D-aspartate (NMDA) receptor antagonist, is commonly used for general pediatric anesthesia. Accumulating evidence has indicated that prolonged exposure to ketamine induces widespread apoptotic cell death in the developing brains of experimental animals. Although mitochondria are known to play a pivotal role in cell death, little is known about the alterations...
Previous studies have demonstrated that mindfulness practice can improve general cognitive control. However, little research has examined whether mindfulness practices affect different cognitive control strategies. According to the dual mechanisms of control (DMC) model, different cognitive control strategies may play distinct roles in individuals' lives. Proactive control allows people to...
The abuse of 3,4-methylenedioxymethamphetamine (MDMA), a psychedelic drug, can lead to a variety of disorders in neural system, including the death of retinal neural cells. MDMA at lower doses does not cause obvious cytotoxicity to photoreceptor cells, indicating potential indirect mechanisms which have not yet been elucidated. This study investigated the effect of MDMA at nontoxic...
Cannabinoid CB1 receptor antagonists have potential therapeutic benefits, but antagonist-elicited cannabis withdrawal has not been reported in humans. Ten male daily cannabis smokers received 8 days of increasingly frequent 20-mg oral Δ⁹-tetrahydrocannabinol (THC) dosages (40-120 mg/d) around-the-clock to standardize cannabis dependence while residing on a closed research unit. On the ninth...
Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, is widely used for analgesia and anesthesia in obstetric and pediatric practice. Recent reports indicate that ketamine causes neuronal cell death in developing rodents and nonhuman primates. The present study assessed the potential dose- and time-dependent neurotoxic effects and associated changes in gene expression after ketamine...