Experimental cell research

Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment.

Experimental cell research October 18, 2018 Trisha Eustaquio, Cheng Z Wang, Christopher K Dugard et al.

Ketamine, an FDA-approved N-methyl-D-aspartate (NMDA) receptor antagonist, is commonly used for general pediatric anesthesia. Accumulating evidence has indicated that prolonged exposure to ketamine induces widespread apoptotic cell death in the developing brains of experimental animals. Although mitochondria are known to play a pivotal role in cell death, little is known about the alterations...