Advanced Science
September 25, 2025
Ye Wang, Lei Liu, Jinghao Wang et al.
2 citations
Current pharmacotherapies for post-traumatic stress disorder (PTSD) are limited by delayed onset and side effects. Despite ketamine exhibiting rapid relief of the core symptoms of PTSD, its clinical efficacy varies considerably depending on the timing of drug delivery. However, the underlying mechanism remains unclear. In this study, the therapeutic effects of early (day 1) and late (day 7)...
Behavioural Pharmacology
July 7, 2025
Kaixi Li, Nan Li, Yuanyuan Chen et al.
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are synthetic tryptamines with hallucinogenic-like properties that are widely abused worldwide. There, however, has been a paucity of research and a lack of available data on their pharmacological properties. The objective of this study was to investigate the safety...
Neuroscience Research
July 1, 2025
Kaixi Li, Nan Li, Yuanyuan Chen et al.
1 citation
Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT2A receptor is...
British Journal of Anaesthesia
May 28, 2025
Jia Huo, Huiming Li, Dan Wang et al.
4 citations
Orexin can induce arousal from general anaesthesia; however, the underlying mechanisms are not fully understood. Nucleus accumbens (NAc), a downstream target of orexinergic neurones, plays a role in regulating consciousness. We aimed to clarify whether and how the NAc mediates the arousal effects of orexin. Fibre photometry was used to track changes of orexinergic afferent activity during...
Analytical Chemistry
April 29, 2025
Zhongbao Han, Zhongyu Zhao, Meiyun Pan et al.
3 citations
A novel method for rapid and sensitive illicit drug screening in biofluids has been developed by employing a paper-based sample collection coupled with ultrasonic desorption-assisted low-temperature plasma ionization mass spectrometry (PBS-LTPI-MS). For optimization, key experimental parameters, such as geometry coordinates, angle, and plasma intensity, were fine-tuned using ketamine as the...
PLoS One
2025
Wei Wang, Dan Wang, Li Liu et al.
3 citations
The widespread use of illegal drugs and their associated problems have emerged as a significant public health concern. This study was conducted to estimate the consumption and prevalence of substance use in selected cities of Guangdong Province through wastewater-based epidemiology. We collected influent wastewater samples from 67 wastewater treatment plants across four cities of Guangdong from...
British Journal of Anaesthesia
December 1, 2023
Wenying Duan, Kang Peng, Hui-Min Qin et al.
BACKGROUND Delayed emergence from general anaesthesia poses a significant perioperative safety hazard. Subanaesthetic doses of ketamine not only deepen anaesthesia but also accelerate recovery from isoflurane anaesthesia; however, the mechanisms underlying this phenomenon remain elusive. Esketamine exhibits a more potent receptor affinity and fewer adverse effects than ketamine and exhibits...
Frontiers in Psychiatry
November 11, 2022
Binyu Teng, Dan Wang, Conghui Su et al.
38 citations
BackgroundThe Multidimensional Assessment of Interoceptive Awareness (MAIA) is a self-report questionnaire developed by Dr. Mehling that has been widely used to assess multiple dimensions of interoceptive awareness. To further improve the MAIA, Mehling developed the Multidimensional Assessment of Interoceptive Awareness, Version 2 (MAIA-2). The goal of this study is to systematically translate...