Namik Kirlic - The Consciousness Library

The role of therapeutic alliance in psilocybin treatment for treatment-resistant depression: A post hoc path analysis.

Journal of Affective Disorders August 1, 2026 Guy M. Goodwin, Scott T Aaronson, Oscar Alvarez et al. 2 citations

The contribution of patient support to psilocybin's antidepressant effects remains uncertain. Relationships between therapeutic alliance (Scale to Assess Therapeutic Relationship-Patient version; STAR-P), psychedelic experience (Five-Dimensional Altered States of Consciousness Questionnaire and Emotional Breakthrough Inventory; 5D-ASC and EBI) and clinical outcomes (Montgomery-Åsberg Depression...

DOI: 10.1016/j.jad.2026.121662 Full text Psilocybin Treatment-resistant depression Psychedelic experience Psychological support +1

Silence is golden: Documenting the speech production of participants and support providers in psilocybin administration sessions for the treatment of post-traumatic stress disorder

Journal of Psychopharmacology July 16, 2026 Robert F. Dougherty, Nadav Liam Modlin, Niall M. Mcgowan et al.

Background: When administered alongside monitoring and support, psilocybin has shown promise in the treatment of multiple psychiatric conditions. However, the contribution and nature of participant support in the context of psychedelic trials are much debated. Aims: We sought to further illustrate the structure and format of the monitoring and support used in Compass Pathfinder Ltd (Compass)...

DOI: 10.1177/02698811261464988 Psilocybin Context archaeology Thematic analysis Focus group +5

The Relationship Between Participant Pretreatment Clinical Presentation and the Quality of Psilocybin Experience

Journal of Clinical Psychopharmacology December 9, 2025 Namik Kirlic, Merve Atli, Sunil Mistry et al.

Purpose/Background: The therapeutic effects of psilocybin treatment are thought to be influenced by the subjective dose-dependent psychedelic experience, as well as the individual participant’s mindset and the treatment environment. However, the relative contribution of an individual’s pretreatment clinical characteristics and their subjective psychedelic experience remains unclear. We examined...

DOI: 10.1097/jcp.0000000000002119 Psilocybin Presentation obstetrics Quality philosophy Medline +3

Investigational psilocybin treatment for post-traumatic stress disorder: a qualitative study of participant experience, trauma engagement, and differences from standard treatment.

EClinicalMedicine December 1, 2025 Nadav Liam Modlin, Victoria Williamson, Guy M. Goodwin et al. 2 citations

Post-traumatic stress disorder (PTSD) is a debilitating condition leading to significant personal and societal burden. Standard treatments frequently demonstrate limited efficacy, leading to persistent symptoms and high dropout rates. Psilocybin has shown promise in treating depression, a condition that is often comorbid with PTSD. We aimed to explore participant experiences of psilocybin...

DOI: 10.1016/j.eclinm.2025.103692 Full text Post-traumatic stress disorder Psychedelic therapy Comp360 psilocybin Patient experience +1

Corrigendum to "The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression" [Journal of Affective Disorders, Volume 372 (2025), Pages 523-532].

J Affect Disord October 10, 2025 Guy M. Goodwin, Scott T Aaronson, Oscar Alvarez et al. correction

Corrigendum to "The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression" [Journal of Affective Disorders, Volume 372 (2025), Pages 523-532].

DOI: 10.1016/j.jad.2025.120352 Psilocybin Treatment-resistant depression Psychedelic experience Unique experience +7

Posterior cingulate cortex downregulation training using fMRI neurofeedback in adolescents with early life adversity exposure: a randomized, single-blind trial.

Translational Psychiatry July 13, 2025 Xiaoqian Yu, Aki Tsuchiyagaito, Masaya Misaki et al. 4 citations

Early life adversity (ELA) disrupts default mode network (DMN) integrity subserving self-referential processes involved in emotional awareness and regulation. Mindfulness training (MT) reduces self-referential processing and down-regulates the DMN. We employed neurofeedback-augmented mindfulness training (NAMT), combining a core mindfulness strategy (focusing on breath) with real-time fMRI...

DOI: 10.1038/s41398-025-03445-w Full text Meditation Awareness practice Mindfulness for adolescents Emotional regulation +11

Clinical conceptualisation of PTSD in psilocybin treatment: disrupting a pre-determined and over-determined maladaptive interpretive framework

Therapeutic Advances in Psychopharmacology June 8, 2025 Nadav Liam Modlin, Victoria Williamson, Carolina Maggio et al. 1 citation

Post-traumatic stress disorder (PTSD) and associated trauma and stressor-related disorders are common and debilitating, presenting significant treatment challenges due to their complex interplay of biological, cognitive, affective, somatic and social factors. Current treatments, while advancing and effective, yield limited efficacy for many individuals, underscoring the need for novel...

DOI: 10.1177/20451253251342319 Psilocybin Anxiety Psychotherapist Cognition +3

ENIGMA-Meditation: Worldwide Consortium for Neuroscientific Investigations of Meditation Practices.

Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Saampras Ganesan, Fernando A Barrios, Ishaan Batta et al. 6 citations

Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past...

DOI: 10.1016/j.bpsc.2024.10.015 Full text Meditation Mindfulness Consortium Enigma +1

The role of the psychedelic experience in psilocybin treatment for treatment-resistant depression.

Journal of Affective Disorders March 1, 2025 Guy M. Goodwin, Scott T Aaronson, Oscar Alvarez et al. 35 citations

To determine the relationships between psilocybin dose, psychedelic experiences, and therapeutic outcome in treatment-resistant depression. For treatment-resistant depression, 233 participants received a single dose of 25, 10, or 1 mg of COMP360 psilocybin (a proprietary, pharmaceutical-grade synthesized psilocybin formulation, developed by the sponsor, Compass Pathfinder Ltd.) with...

DOI: 10.1016/j.jad.2024.12.061 Full text Magic mushrooms Treatment-resistant depression Psychedelics psilocybin Hallucinogens +8

Compass Psychological Support Model for COMP360 Psilocybin Treatment of Serious Mental Health Conditions

American Journal of Psychiatry 2025 Namik Kirlic, Molly Lennard-Jones, Merve Atli et al. 27 citations

The psychedelic experience can be challenging. There is a need for a structured framework for providing psychological support to individuals with mental health conditions receiving investigational psilocybin treatment. The primary benefit of such a framework is to support a safe and meaningful psilocybin experience. It also enables future research on the facets of psychological support and/or...

DOI: 10.1176/appi.ajp.20230884 Psilocybin Mental health Psychotherapist Compass +2

Augmenting mindfulness training through neurofeedback: a pilot study of the pre-post changes on resting-state functional connectivity in typically developing adolescents.

Frontiers in Neuroscience 2024 Kelly T Cosgrove, Aki Tsuchiyagaito, Zsofia P Cohen et al. 3 citations

Mindfulness training has been shown to promote positive mental health outcomes and related changes in neural networks such as the default mode network, which has a central node in the posterior cingulate cortex (PCC). Previous work from our group reported on the impact of a novel, neurofeedback augmented mindfulness training (NAMT) task on regulation of PCC hemodynamic activity in typically...

DOI: 10.3389/fnins.2024.1397234 Full text Mindfulness Adolescence FMRI Neurofeedback Functional connectivity +1

Optimizing outcomes in psilocybin therapy: Considerations in participant evaluation and preparation.

Journal of Affective Disorders April 1, 2023 Nadav Liam Modlin, Tammy M Miller, James J Rucker et al. 30 citations

Recent studies have demonstrated the promise of psilocybin therapies in creating positive changes for those with poor mental health across multiple diagnostic categories, including major depressive disorder (MDD), end-of-life anxiety, and obsessive-compulsive disorder (OCD). While there may be a large population that is eligible to participate in psilocybin therapy based on psychiatric...

DOI: 10.1016/j.jad.2023.01.077 Full text Psychedelic therapy Optimizing psychedelics Treatment outcomes Psilocybin treatment +3

Self-regulation of the posterior cingulate cortex with real-time fMRI neurofeedback augmented mindfulness training in healthy adolescents: A nonrandomized feasibility study

Cognitive Affective & Behavioral Neuroscience March 15, 2022 Namik Kirlic, Zsofia P Cohen, Aki Tsuchiyagaito et al. 29 citations

Mindfulness training (MT) promotes the development of one's ability to observe and attend to internal and external experiences with objectivity and nonjudgment with evidence to improve psychological well-being. Real-time functional MRI neurofeedback (rtfMRI-nf) is a noninvasive method of modulating activity of a brain region or circuit. The posterior cingulate cortex (PCC) has been hypothesized...

DOI: 10.3758/s13415-022-00991-4 Full text Mindfulness Neurofeedback Posterior cingulate Anterior cingulate cortex +8

Papers