Background: Psilocybin is being studied for depression, but little is known about how it interacts with common antidepressants. Limited data suggest that psilocybin’s effects may be diminished by serotonergic antidepressants acutely and even after a medication washout period. Aims: To learn the extent to which antidepressants may diminish the effects of psilocybin-containing mushrooms both...
Background: Emerging literature suggests that classic psychedelics may have efficacy in treating mood and substance use disorders in humans. This has raised questions regarding the primary therapeutic mechanism of these compounds. Here, we hypothesize that the reversal of and resilience against learned helplessness may be an important driver of the therapeutic mechanisms of classic...
The relationship between subjective drug experience and antidepressant outcomes for ketamine derivatives is poorly understood but of high clinical relevance. Esketamine is the patented (S)-enantiomer of ketamine and has regulatory approval for psychiatric applications. We examined the relationship between acute dissociation, as measured by the Clinician-Administered Dissociative States Scale...
Interest in experiences that can broadly be considered religious, spiritual, mystical, and self-transcendent is growing – largely due to recent advances in psychedelic research (Yaden et al., 2021)...
Psychedelic use is anecdotally associated with belief changes, although few studies have tested these claims. Characterize a broad range of psychedelic occasioned belief changes. A survey was conducted in 2374 respondents who endorsed having had a belief changing psychedelic experience. Participants rated their agreement with belief statements Before and After the psychedelic experience as well...
As individuals and communities around the world confront mounting physical, psychological, and social threats, three complimentary mind-body-spirit pathways toward health, wellbeing, and human flourishing remain underappreciated within conventional practice among the biomedical, public health, and policy communities. This paper reviews literature on psychedelic science, contemplative practices,...
Background: A trial of psilocybin (COMP360) versus escitalopram for major depressive disorder (MDD) was reported as negative, as there was no significant difference in the primary outcome, mean change in the 16-item Quick Inventory of Depressive Symptomatology–Self-Report (QIDS SR-16). However, analyses using three other depression scales (17-item Hamilton Depression Rating Scale [HAMD-17],...
Background: Psilocybin is being studied for depression, but little is known about how it interacts with common antidepressants. Limited data suggests that psilocybin’s effects may be diminished by serotonergic antidepressants acutely and even after a medication washout period.Aims: To learn the extent to which serotonergic antidepressants may diminish psilocybin’s effects both concurrently and...
Abstract: Spiritual experiences could be beneficial in the context of clinical interventions and may become an important avenue for helping people who suffer from mental illness. Mindfulness and other meditation practices, which can sometimes give rise to spiritual experiences, have become a standard practice in healthcare. More recently, psychedelic compounds are poised to make a breakthrough...
Abstract Mystical experiences are among the most well-studied spiritual experience. This chapter defines mystical experience as inner experiences involving an intensely felt fading of the sense of self and/or feelings of increased connectedness, up to and including the sense of complete unity. These kinds of feelings go well beyond our normal day to day sense of self-awareness. In ordinary...
Abstract Where do spiritual experiences come from? There is, of course, a theological/philosophical level as well as a more practical level to this question. But as shown time and again in the preceding chapters of this book, the Jamesian approach of setting aside theological questions can be taken so as to instead focus on scientifically tractable subjects, such as the conditions that seem to...
Abstract Among life’s biggest questions—up there with the origins of the universe—is: Why and how are people aware at all? The sense of awareness, or what is commonly called “phenomenal consciousness,” or just consciousness, is not currently understood by scientists. Scientists do, of course, understand many of the contents of consciousness, such as mental processes like perceptions, thoughts,...
Abstract: According to William James, to understand a person’s beliefs, then seek to learn more about that person’s temperament and life circumstances. Thus, this chapter focuses on the story of William James’s life and his influences to understand how he developed the worldview that he brought to The Varieties of Religious Experience. James’s life was in many ways a study in contrasts. He...
This Viewpoint presents impediments to the clinical application of psychedelics created by extreme shifts in public perception while advocating further study and encouraging the dispute of claims not supported by available evidence.
Evidence suggests that psychedelics bring about their therapeutic outcomes in part through the subjective or qualitative effects they engender and how the individual interprets the resulting experiences. However, psychedelics are contraindicated for individuals who have been diagnosed with certain mental illnesses, on the grounds that these subjective effects may be disturbing or otherwise...
Abstract Each chapter of Part II considers one or more of the kinds of spiritual experience described in the typology introduced in the previous chapter. The first chapter of Part II focuses on numinous experience, the feeling of being in touch with divinity or God. This kind of spiritual experience may constitute the prototypical religious or spiritual experience. Our own research data show...
Abstract Spiritual experiences have occurred in people around the world and throughout history, up to and including the present day. The founders of every major religion described them, philosophers since the ancient Greeks have pondered them, and according to recent Gallup polls, about 30% of people in the United States and the United Kingdom still report them. A century ago, in The Varieties...
The acute subjective effects of psychedelics are responsive to users’ expectations and surroundings (i.e., “set and setting”). Accordingly, a great deal of thought has gone into designing the psychosocial context of psychedelic administration in clinical settings. But what theoretical paradigms inform these considerations about set and setting? Here, we describe several historical, sociological...
In this study, we describe the development and initial validation of two psychometric scales for measuring psychedelic integration. Psychedelic integration refers to the post-acute period of time following psychedelic drug administration. We created the Integration Engagement Scale (IES) to capture positive behavioral engagement with integration and the Experienced Integration Scale (EIS) to...
End of life and palliative care has improved in recent decades but the psychopharmacological options available to clinicians and patients in these contexts remain limited. In particular, psychological factors such as depression, existential distress, and well-being remain challenging to address with current medications. Here, we review recent research on the use of psychedelics in clinical...
Several pilot studies have provided evidence supporting the potential of classic psychedelics like psilocybin in the treatment of substance use disorders (SUDs). If larger trials confirm efficacy, classic psychedelic-assisted psychotherapy may eventually be integrated into existing addiction treatments such as cognitive behavioral therapy, contingency management, and medication-assisted...
Abstract Psychedelic substances produce unusual and compelling changes in conscious experience that have prompted some to propose that psychedelics may provide unique insights explaining the nature of consciousness. At present, psychedelics, like other current scientific tools and methods, seem unlikely to provide information relevant to the so-called “hard problem of consciousness,” which...
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ABSTRACT Do psychological traits predict philosophical views? We administered the PhilPapers Survey, created by David Bourget and David Chalmers, which consists of 30 views on central philosophical topics (e.g., epistemology, ethics, metaphysics, philosophy of mind, and philosophy of language) to a sample of professional philosophers (N = 314). We extended the PhilPapers survey to measure a...