Brain StimulationMay 21, 2026Lucas Dwiel, Mackenzi L. Prina, Elise Bragg et al.
A leading theory for how psychedelics are able to produce robust clinical improvement and preclinical behavioral changes is that psychedelics act through neuroplastic mechanisms to induce lasting structural and functional alterations in neural circuits. However, psychedelics produce these effects across wide swaths of the brain. Based on our prior work, we hypothesized that engaging a specific...
Background: Brainstem reticular formation (BRF) is crucially involved in regulating arousal, making it a potential target for reversing general anesthesia. The transnasal approach provides a minimally invasive access to the ventral brainstem. However, whether this approach can effectively modulate arousal remains unknown. Objective: To evaluate the efficacy of transnasal BRF electrical...
Brain StimulationApril 1, 2024Yang Bai, Li Yang, Xiangqiang Meng et al.
BACKGROUND The complexity of the neurophysiological mechanisms underlying human consciousness is widely acknowledged, with information processing and flow originating in cortex conceived as a core mechanism of consciousness emergence. Combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is considered as a promising technique to understand the effective...
RECOVER is a randomized sham-controlled trial of vagus nerve stimulation and the largest such trial conducted with a psychiatric neuromodulation intervention. To describe pre-implantation baseline clinical characteristics and treatment history of patients with unipolar, major depressive disorder (MDD), overall and as a function of exposure to interventional psychiatric treatments (INTs),...
Functions of the human insula have been explored extensively with neuroimaging methods and intracranial electrical stimulation studies that have highlighted a functional segregation across its subregions. A recently developed cytoarchitectonic map of the human insula has also segregated this brain region into various areas. Our knowledge of the functional organization of this brain region at...
Brain StimulationMay 1, 2023Frederic Gilbert, Marcello Ienca, Mark Cook
Novel usages of brain stimulation combined with artificially intelligent (AI) systems promise to address a large range of diseases. These new conjoined technologies, such as brain-computer interfaces (BCI), are increasingly used in experimental and clinical settings to predict and alleviate symptoms of various neurological and psychiatric disorders. Due to their reliance on AI algorithms for...
Funding Information: GC was funded by Funda??o para a Ci?ncia e Tecnologia (FCT; Portugal) through a PhD Scholarship (SFRH/BD/130210/2017). AJO-M was funded by FCT (Portugal) through a Junior Research and Career Development Award from the Harvard Medical School ? Portugal Program (HMSP-ICJ/0020/2011). GC and AJO-M were supported by grant PTDC/MED-NEU/31331/2017, and AJO-M by grant...
Brain StimulationSeptember 1, 2021M. Davila, A. Hess, Ananya Louviere et al.
Background: Repetitive transcranial magnetic stimulation (rTMS) is a neurostimulatory technique approved for the treatment of major https://doi.org/10.1016/j.brs.2021.07.023 depressive disorder (MDD) impacting orbital frontal cortex functioning. We have previously identified significant changes in ratings for several standard metrics for depression, anxiety, pain and ADHD after 6 weeks of...
BACKGROUND Brain stimulation, both invasive and non-invasive, is increasingly being used to modulate mood and other aspects of subjective experience in various neuropsychiatric conditions. Because this enterprise is deeply dependent on first-person reports provided by patients, sham stimulation is routinely employed to control for demand characteristics and placebo effects. However, a general...
Brain StimulationApril 28, 2020Kristian H. R. Jensen, Sofie Trolle Pedersen, Mette Vinther Hansen et al.2 citations
Electroconvulsive therapy (ECT) is often the last resort in medically treatment-resistant patients. The mechanisms of its efficacy are still somewhat poorly understood. However, it is clearly a highly effective treatment for severe and psychotic depression, as well as other severe neuropsychiatric conditions [1]. This case-report attempts to offer a perspective on the impact of ECT on sensorial...
Meditation can be conceptualized as a family of complex emotional and attentional regulatory training regimes developed for various ends, including the cultivation of well-being and emotional balance. Previous studies have demonstrated that meditation may have positive effects on self-awareness, emotion regulation, attention processes, and also structural neuroplasticity [1]. However, the...
Brain StimulationJune 27, 2015Arman Abrahamyan, Colin W.G. Clifford, Ehsan Arabzadeh et al.
Background: Transcranial magnetic stimulation (TMS) is a popular functional mapping tool in cognitive and sensory neuroscience. While strong TMS typically degrades performance, two recent studies have demonstrated that weak TMS, delivered to visual cortex, can improve performance on simple visual tasks. The improvement was interpreted as the summation of visually-evoked and TMS-elicited...
Brain StimulationOctober 2009Giacomo Koch, Francesco Mori, Claudia Codecà et al.
In animal models, the cannabinoid system has been convincingly implicated in the regulation of long-lasting synaptic plasticity. Both long-term potentiation (LTP) and depression (LTD) phenomena can be induced in the human motor cortex by transcranial magnetic theta burst stimulation (TBS). Here, we explored the potential involvement of the cannabinoid system in TBS-induced synaptic plasticity...