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Jean-Claude Alvarez

4 papers in the library · 6 citations · publishing 2022-2025

Papers

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Understanding cannabis use and car crashes: Insights from a randomized trial using a driving simulator on THC blood levels and subjective measures of sleepiness and performance.

Journal of safety research December 1, 2025 Bibiana Cardozo, Sarah Hartley, Nicolas Simon et al.

To investigate whether THC inhalation increases driving collisions, and to explore the relationship between car crashes and self-assessed driving ability as measured by Visual Analog Scales (VAS) and the Karolinska Sleepiness Scale, 30 male volunteers aged 18-30 years old, with a BMI of 18.5-26.2 Kg/m2, moderate tobacco and caffeine consumption, and at least one year of cannabis use either...

DOI: 10.1016/j.jsr.2025.09.005 (opens in new tab) Full text (opens in new tab) THC Car collisions Car crashes Driving behavioral compensation +3

Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.

Neuropharmacology November 1, 2024 Thi Mai Loan Nguyen, Jean-Philippe Guilloux, Céline Defaix et al. 3 citations

(R,S)-ketamine (ketamine) has rapid and sustained antidepressant (AD) efficacy at sub-anesthetic doses in depressed patients. A metabolite of ketamine, including (2R,6R)-hydroxynorketamine ((6)-HNKs) has been reported to exert antidepressant actions in rodent model of anxiety/depression. To further understand the specific role of ketamine's metabolism in the AD actions of the drug, we evaluated...

DOI: 10.1016/j.neuropharm.2024.110065 (opens in new tab) Full text (opens in new tab) R,s-ketamine Cytochrome p450 inhibitor Fluconazole Gaba +10

Can inhaled cannabis users accurately evaluate impaired driving ability? A randomized controlled trial.

Frontiers in Public Health 2023 Sarah Hartley, Nicolas Simon, Bibiana Cardozo et al.

To study the effect of inhaled cannabis on self-assessed predicted driving ability and its relation to reaction times and driving ability on a driving simulator. 30 healthy male volunteers aged 18-34: 15 chronic (1-2 joints /day) and 15 occasional (1-2 joints/week) consumers. Self-assessed driving confidence (visual analog scale), vigilance (Karolinska), reaction time (mean reciprocal reaction...

Loss of Consciousness and Visual Hallucinations Related to 5-MeO-DALT Intake, a Case Report Confirmed by Toxicological Analyses.

Journal of Analytical Toxicology August 13, 2022 Laurène Dufayet, Jérôme Langrand, Jean-Claude Alvarez et al. 3 citations

5-MeO-DALT or 5-methoxy-N,N-diallyltryptamine is a derivative of tryptamines, consumed for its hallucinogenic and entheogenic effects. We report the case of a 46-year-old-man, presenting with a brief loss of consciousness and visual hallucinations, after the consumption of three 5-MeO-DALT tablets bought online. Liquid chromatography coupled to tandem mass spectrometry method was performed, and...