Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions.
Neuropharmacology November 1, 2024 Thi Mai Loan Nguyen, Jean-Philippe Guilloux, Céline Defaix et al. 3 citations
(R,S)-ketamine (ketamine) has rapid and sustained antidepressant (AD) efficacy at sub-anesthetic doses in depressed patients. A metabolite of ketamine, including (2R,6R)-hydroxynorketamine ((6)-HNKs) has been reported to exert antidepressant actions in rodent model of anxiety/depression. To further understand the specific role of ketamine's metabolism in the AD actions of the drug, we evaluated...