Journal of Analytical Toxicology
July 22, 2023
Alice Ameline, Morgane Baudry, Delphine Garnier et al.
1 citation
3-Hydroxyphencyclidine (3-OH-PCP) is a hydroxy derivative of phencyclidine, synthesized in 1978 to investigate the structure-activity relationship of phencyclidine derivates. In vitro studies have shown that 3-OH-PCP, like phencyclidine, acts on the N-methyl-D-aspartate receptor and has a higher affinity for this receptor than phencyclidine. The authors report the case of a 38-year-old man,...
Forensic Chemistry
September 20, 2021
Pascal Kintz, J. Raul, Alice Ameline
4 citations
Abstract Although it has been published during the last 15 years that hallucinogens derived from new psychoactive substances are increasingly abused, the old psychedelic agents are still used. Among these vegetal compounds, magic mushrooms are frequently mentioned. The major ingredient of the Psilocybe species is psilocybin, which is rapidly converted into psilocin in the human body. Therefore,...
International Journal of Legal Medicine
July 1, 2021
Pascal Kintz, Jean-Sébastien Raul, Alice Ameline
8 citations
The objective of this publication is to present the interest of collecting several keratinous specimens in order to document possible drug impairment at the time of the assault, when knowledge solely occurred 7 months after. A subject committed a murder and within minutes after the crime self-inflicted serious wounds. He was charged to the hospital where he slowly recovered. After several...
Drug Testing and Analysis
June 1, 2021
Islam Amine Larabi, Fanny Zerizer, Alice Ameline et al.
23 citations
The aim of this study was to identify new markers of deschloro-N-ethyl-ketamine (O-PCE), a ketamine analogue that has been involved in acute intoxications with severe outcomes including death and whose metabolism has never been studied before. In vitro study after 2-h incubation with pooled human liver microsomes (HLMs) cross-checked by the analysis of urine and hair from a 43-year-old O-PCE...
Forensic Sciences Research
2021
Nadia Arbouche, Pascal Kintz, Cecile Zagdoun et al.
16 citations
3-Methoxyphencyclidine (3-MeO-PCP) is a new psychoactive substance that belongs to the phencyclidines family, first identified in Europe in 2012. This drug presents a stronger binding to N-methyl-D-aspartate (NMDA) receptors when compared to phencyclidine, which results in more potent effects, even at low concentrations. Very few articles have been published regarding 3-MeO-PCP in forensic...
Drug Testing and Analysis
October 23, 2020
Pascal Kintz, Alice Ameline, J. Raul
10 citations
For 40 years, hair tests have been presented as the best approach to document long-term consumption of a drug. This unique property has found numerous applications in clinical, forensic, and occupational toxicology. However, since the beginning of its implementation in biology, external contamination, with an associated risk of false positive result, has been presented as the key in the final...
Annales de Toxicologie Analytique
December 1, 2019
F. Grossenbacher, Y. Cazaubon, Catherine Feliu et al.
Summary We report five cases involving use of 3 Meo-PCP (3 methoxyphencyclidine) with 2 fatalities and 3 non-fatal cases seen in France in 2018. PCP (Phencyclidine) is an arylcyclohexanexylamine, synthesised by Maddox in 1956, and has a potent dissociative anaesthetic drug. One derivative 3 Meo-PCCP appeared on the street market in 2012 with potency slightly lower than PCP. The three non-fatal...
Journal of Analytical Toxicology
May 1, 2019
Alice Ameline, Hugues Greney, Laurent Monassier et al.
In this article, two fatal cases related to the use of 3-methoxyphencyclidine (3-MeO-PCP) are described. This compound is a new psychoactive substance that belongs to the phencyclidine family. In the recent period, this dissociative drug has gained interest because of its proposal as a legally available alternative to phencyclidine in some countries. The scientific literature related to...
International Journal of Legal Medicine
March 1, 2019
Pascal Kintz, Alice Ameline, Alexis Walch et al.
The abuse of new psychoactive substances (NPS) has been dramatically increasing all around the world since the late 2000s. The availability of hundreds of NPS in the past decade is challenging for both public health and global drug policies. A 39-year-old woman, known as a multidrug addict, was murdered by her partner by ligature strangulation. A comprehensive toxicological screening by gas...
Current Pharmaceutical Biotechnology
2017
Alice Ameline, Audrey Farrugia, Jean-Sébastien Raul et al.
The abuse of new psychoactive substances or NPS has been dramatically increasing all around the world since the last half of the year 2000 and has become a serious public health problem. NPS are a challenge for the worldwide forensic community due to the difficulties to accurately document the cases. The N-benzylmethoxy (NBOMe) group is a new class of hallucinogenic designer drugs and has...