Delphine Joseph

2 papers in the library · 31 citations · publishing 2021-2023

Papers

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Characterization of extensive 2-fluorodeschloroketamine metabolism in pooled human liver microsomes, urine and hair from an addicted patient using high-resolution accurate mass spectrometry.

Journal of Analytical Toxicology July 22, 2023 Delphine Joseph, Camille Lesueur, Fanny Zerizer et al. 8 citations

2-Fluorodeschloroketamine (2F-DCK) is a ketamine derivative involved in acute intoxications and deaths. The aim of this study is to investigate its metabolism using pooled human liver microsomes (pHLMs) and to apply it to authentic samples (urine, hair and seized materials) from a drug user. 2F-DCK (100 µM) incubates with pHLMs were analyzed by liquid chromatography-high-resolution accurate...

DOI: 10.1093/jat/bkad030 Full text

Metabolic profiling of deschloro-N-ethyl-ketamine and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry.

Drug Testing and Analysis June 1, 2021 Islam Amine Larabi, Fanny Zerizer, Alice Ameline et al. 23 citations

The aim of this study was to identify new markers of deschloro-N-ethyl-ketamine (O-PCE), a ketamine analogue that has been involved in acute intoxications with severe outcomes including death and whose metabolism has never been studied before. In vitro study after 2-h incubation with pooled human liver microsomes (HLMs) cross-checked by the analysis of urine and hair from a 43-year-old O-PCE...

DOI: 10.1002/dta.3007 Full text Deschloro-n-ethyl-ketamine Hair High-resolution mass spectrometry Human liver microsomes +1