World Journal of Psychiatry
June 30, 2026
Jing Tong, Jun Cheng, Shu-Min Gao et al.
BACKGROUND Schizophrenia is a chronic mental disorder, which affects about 0.75% of the global population. Most patients show negative symptoms and cognitive impairment, and often accompanied by anxiety and depression. These persistent negative emotions significantly impair the treatment compliance, functional recovery and quality of life of patients. Although mindfulness-based stress reduction...
bioRxiv
June 3, 2026
Yanxia Liang, Lingjun Wang, Yajie Li et al.
preprint
Ketamine produces rapid antidepressant effects but is constrained by psychotomimetic properties and abuse potential. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) shows antidepressant-like efficacy without N-methyl-D-aspartate receptor (NMDAR) blockade, yet its upstream targets remain unclear. Here we show that HNK potentiates hippocampal excitatory transmission and reverses...
Medicine
November 1, 2024
Xiangqian Wan, Ming Li, Xiantao Li et al.
8 citations
The aim of this randomized, double-blind placebo-controlled clinical trial was to study the effects of subclinical doses of esketamine on postpartum depression and pain following elective cesarean sections. This randomized, double-blind placebo-controlled trial included 150 pregnant women undergoing elective cesarean sections. After umbilical cord clamping, participants received either...
Neuron
September 25, 2024
Ming Li, Xue-Ke Yang, Jian Yang et al.
30 citations
Erasing traumatic memory during memory reconsolidation is a promising retrieval-extinction strategy for post-traumatic stress disorder (PTSD). Here, we developed an acute social defeat stress (SDS) mouse model with short-term and re-exposure-evoked long-term social avoidance. SDS-associated traumatic memories were identified to be stored in basolateral amygdala (BLA) engram cells. A single...
Behavioural Brain Research
September 15, 2015
Natashia Swalve, Scott T Barrett, Rick A Bevins et al.
Nicotine is a widely-abused drug, yet its primary reinforcing effect does not seem potent as other stimulants such as cocaine. Recent research on the contributing factors toward chronic use of nicotine-containing products has implicated the role of reinforcement-enhancing effects of nicotine. The present study investigates whether phencyclidine (PCP) may also possess a reinforcement-enhancement...
Clinical Psychopharmacology and Neuroscience
December 1, 2012
N. Volf, G. Hu, Ming Li
Objective Iptakalim is a putative ATP-sensitive potassium (KATP) channel opener. It is also a novel nicotinic acetylcholine receptor (nAChR) blocker and can antagonize nicotine-induced increase in dopamine release in the nucleus accumbens. Our recent work also shows that iptakalim exhibits a clozapine-like atypical antipsychotic profile, indicating that iptakalim may possess a dual action...
Schizophr Res
November 1, 2005
Shitij Kapur, Romina Mizrahi, Ming Li
510 citations
How does an excess in a neurochemical lead someone to being paranoid about the intentions of their neighbour? And why does blocking a dopamine receptor improve this symptom? In this article we present a heuristic framework which attempts to link the biology, phenomenology and pharmacology of psychosis. Focussing on dopamine's role in reward prediction and motivational salience we propose that...