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Shitij Kapur

5 papers in the library · 3,787 citations · publishing 2003-2015

Papers

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Sensorimotor gating, cannabis use and the risk of psychosis

Schizophrenia Research May 1, 2015 T. Winton-Brown, V. Kumari, F. Windler et al.

Sensorimotor gating, measured as the modification of eye blink startle reflexes to loud acoustic stimuli by quieter preceding stimuli, is altered in those with psychosis, their relatives and those at high clinical risk for psychosis. Alterations have also been shown in cannabis users, albeit to a lesser extent, and cannabis is a known risk factor for the onset of psychosis in clinically and...

DOI: 10.1016/j.schres.2015.02.017 (opens in new tab) Full text (opens in new tab)

Cannabidiol inhibits THC-elicited paranoid symptoms and hippocampal-dependent memory impairment

Journal of Psychopharmacology October 5, 2012 Amir Englund, Paul D. Morrison, Judith Nottage et al. 463 citations

Community-based studies suggest that cannabis products that are high in Δ⁹-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue because THC and CBD can be administered in pure form, under controlled conditions. In a between-subjects design, we tested the hypothesis that pre-treatment...

DOI: 10.1177/0269881112460109 (opens in new tab) Cannabidiol Cannabis Paranoia Placebo +4

The phenomenology of acute THC-psychosis

European Psychiatry 2009 Paul D. Morrison, Shitij Kapur, R. Murray 1 citation

It has long been known that cannabis can elicit an acute psychotic reaction. Recent work shows that, of the 60 cannabinoid molecules in the plant, delta-9-tetrahydrocannibinol is responsible for the central effects of cannabis. Here we aimed to investigate, in more detail, the psychological effects of synthetic intravenous THC in healthy subjects. Over 2 experimental sessions, participants...

DOI: 10.1016/s0924-9338(09)70379-7 (opens in new tab)

From dopamine to salience to psychosis--linking biology, pharmacology and phenomenology of psychosis.

Schizophr Res November 1, 2005 Shitij Kapur, Romina Mizrahi, Ming Li 510 citations

How does an excess in a neurochemical lead someone to being paranoid about the intentions of their neighbour? And why does blocking a dopamine receptor improve this symptom? In this article we present a heuristic framework which attempts to link the biology, phenomenology and pharmacology of psychosis. Focussing on dopamine's role in reward prediction and motivational salience we propose that...

DOI: 10.1016/j.schres.2005.01.003 (opens in new tab)