International Journal of Advanced Research
April 30, 2023
Dimple Gupta, Chirag Ambaliya, Aman Ankur et al.
Background:Classical psychedelics are a group of drugs which act as agonists on the serotonin-2A (5-HT2A) receptor. Evidence suggests they may have a uniquely rapid and enduring positive effect on mood. However, marked heterogeneity between methodological designs in this emerging field remains a significant concern. Aims:To determine how differences in the type of psychedelic agent used and the...
Pharmaceuticals
April 21, 2023
Thi Mai Loan Nguyen, Fabrice Jollant, Laurent Tritschler et al.
Around 700,000 people die from suicide each year in the world. Approximately 90% of suicides have a history of mental illness, and more than two-thirds occur during a major depressive episode. Specific therapeutic options to manage the suicidal crisis are limited and measures to prevent acting out also remain limited. Drugs shown to reduce the risk of suicide (antidepressants, lithium, or...
Frontiers in Pharmacology
April 18, 2023
María Salud García-Gutiérrez, Daniela Navarro, Amaya Austrich-Olivares et al.
Introduction: This study aims to further characterize cannabidiol’s pharmacological and molecular profile as an antidepressant.Methods: Effects of cannabidiol (CBD), alone or combined with sertraline (STR), were evaluated in male CD1 mice (n = 48) exposed to an unpredictable chronic mild stress (UCMS) procedure. Once the model was established (4 weeks), mice received CBD (20 mg·kg-1, i.p.), STR...
American journal of physiology. Cell physiology
April 17, 2023
Gavin P. Schmitz, Bryan L. Roth
G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the human genome. Even though perhaps 30% of approved medications target GPCRs, they interact with only a small number of them. Here, we consider whether there might be new opportunities for transformative therapeutics for neuropsychiatric disorders by specifically targeting both known and understudied...
Revista Contemporânea
April 17, 2023
João Moreno Vilas Boas
A Ayahuasca é uma poderosa bebida psicoativa que tem sido usada há séculos por comunidades indígenas na América do Sul para fins espirituais e medicinais. A bebida é feita fervendo o cipó da ayahuasca (Banisteriopsis caapi) e as folhas da planta chacrona (Psychotria viridis), criando uma potente experiência psicadélica que pode durar várias horas. Nos últimos anos, tem havido um interesse...
Ciencia Latina Revista Científica Multidisciplinar
April 11, 2023
Franklin Andrés Álvarez Cortez, Daicy Paola Arias Salazar
En la actualidad el uso excesivo de antidepresivos de origen químico en el Ecuador ha aumentado en los últimos años, con el tiempo el abuso de antidepresivos, bloquea la acción del neurotransmisor que es el responsable de mantener en equilibrio el estado de ánimo (serotonina), ocasionando en las personas altos niveles de depresión y ansiedad, derrames o lesiones cerebrales, pérdida de memoria e...
Frontiers in Psychiatry
April 5, 2023
Sharday Mosurinjohn, Leor Roseman, Manesh Girn
54 citations
Contemporary research on serotonergic psychedelic compounds has been rife with references to so-called ‘mystical’ subjective effects. Several psychometric assessments have been used to assess such effects, and clinical studies have found quantitative associations between ‘mystical experiences’ and positive mental health outcomes. The nascent study of psychedelic-induced mystical experiences,...
Cureus
April 2023
Asila A Ferguson, Aujala Irfan Khan, Baraa Abuzainah et al.
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder that affects approximately 2% of the human population. Traditional treatment of OCD includes selective serotonin reuptake inhibitor (SSRI) or serotonin reuptake inhibitor (SRI) treatment along with cognitive behavioral therapy (CBT). Nearly 25%-30% of OCD patients do not respond to SSRIs. Glutamatergic agents are currently being...
Neuropharmacology
April 1, 2023
Zhi-Peng Yu, Qiong Li, Zhou-Xiao Wu et al.
7 citations
Serotoninergic psychedelics induced extensive alterations in perception and cognition, which has been attributable to its disruptive effect on oscillatory rhythms of prefrontal cortex. However, there is a lack of information how serotoninergic psychedelics affect the intra-prefrontal network, which intrinsically interact to accomplish perceptual processing. Uncovering the altered neural network...
Neurochemical Research
April 1, 2023
Jared VanderZwaag, Torin Halvorson, Kira Dolhan et al.
25 citations
There is much excitement surrounding recent research of promising, mechanistically novel psychotherapeutics - psychedelic, anesthetic, and dissociative agents - as they have demonstrated surprising efficacy in treating central nervous system (CNS) disorders, such as mood disorders and addiction. However, the mechanisms by which these drugs provide such profound psychological benefits are still...