2023
Ovidio Baquero Ramírez, Ariel Enrique Pastrana Arias
La 3,4-metilendioximetanfetamina (MDMA) se clasifica como un entactógeno que produce sentimientos de apertura emocional y relación. Una característica única de la MDMA es que las personas tienden a tomar esta droga de manera selectiva en situaciones sociales y/o íntimas. Aunque se reconoce que la MDMA tiene riesgo de abuso, los estudios preclínicos informan que tiene efectos de refuerzo débiles...
NeuroImage: Clinical
2023
Daphne E Boucherie, Liesbeth Reneman, Henricus G. Ruhé et al.
Selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and (es)ketamine are used to treat major depressive disorder (MDD). These different types of medication may involve common neural pathways related to glutamatergic and GABAergic neurotransmitter systems, both of which have been implicated in MDD pathology. We conducted a systematic review...
Vitamins and hormones
2023
Ayman Mukerji Househam
Epigenetics are heritable changes in the rate of gene expression without any modification of the DNA sequence and occur in response to environmental changes. Tangible changes to the external surroundings may be practical causes for epigenetic modifications, playing a potential evolutionary role. While fight, flight, or freeze responses once served a concrete role in survival, modern humans may...
Molecular Psychiatry
2023
Gilly Wolf, Sandeep Singh, Karin Blakolmer et al.
Schizophrenia is a widespread psychiatric disorder that affects 0.5-1.0% of the world's population and induces significant, long-term disability that exacts high personal and societal cost. Negative symptoms, which respond poorly to available antipsychotic drugs, are the primary cause of this disability. Association of negative symptoms with cortical atrophy and cell loss is widely reported....
Progress in Brain Research
2023
Kenji Hashimoto
Neuroinflammation plays a key role in the pathogenesis of major depressive disorder (MDD), including treatment-resistant depression (TRD). Patients with TRD have higher levels of inflammatory biomarkers compared with responders to antidepressants. Multiple lines of evidence suggest that the gut-microbiota-brain axis via the vagus nerve plays a key role in neuroinflammation. Preclinical and...
Deep Blue (University of Michigan)
2023
Nicolas G. Glynos
N,N-dimethyltryptamine (DMT) belongs to a class of drugs known as serotonergic psychedelics, which produce profound shifts in consciousness by dramatically altering perception and causing hallucinatory phenomena. In humans, DMT has a rapid onset and the effects, which include feelings of dissociation from external reality, entering into an ‘otherworldly dimension’, and intense internal visual...
Schizophrenia
2023
Alaina M Jaster, Javier González-Maeso
Head-twitch response (HTR) allows for the detection and classification of behavior associated with serotonin 2A receptor (5-HT_2AR) activation upon psychedelic administration in rodent models. This activation and functional output can be utilized to provide insights into molecular mechanisms associated with psychosis and to identify signaling processes related to existing and novel...
Frontiers in Psychiatry
2023
Alexander Kaltenboeck, Elisa Foerster, Sabrina Strafner et al.
A 28-year-old man was admitted to our psychiatric ward with severe obsessive-compulsive disorder (OCD) and comorbid depression. At intake, obsessive-compulsive symptoms were present most time of the day and were related to an intense fear of causing interpersonal misunderstandings. Various treatment attempts, including cognitive-behavioural therapy (CBT) with exposure and response prevention...
Sao Paulo Medical Journal
2023
Caroline Darold Vieira, Mateus Gustavo Favaro, Renan Barros Lopes et al.
Case report: A 57-year-old woman was referred to our service after noticing difficulty in coordinating the movements of the right hand. The symptoms occurred after she consumed ayahuasca in a religious ceremony and persisted after the psychedelic effects weaned off. On the first evaluation, she had right hemiataxia and increased blood pressure (200/100 mmHg). The head computed tomography (CT)...
Current reviews in clinical and experimental pharmacology
2023
Rabeet Tariq
5 citations
Psychedelics might be the oldest psychoactive agents known to be used for inducing religious or mystical experiences. Their strong psychoactive effect was discovered accidentally in 1943 after the synthesis of Lysergic acid diethylamide (LSD) in 1937. These drugs became a mainstream area of research following the synthesis of LSD; however, several political and social factors led to their ban...