American journal of physiology. Cell physiology

G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.

American journal of physiology. Cell physiology April 17, 2023 Gavin P. Schmitz, Bryan L. Roth

G protein-coupled receptors (GPCRs) constitute the largest family of druggable genes in the human genome. Even though perhaps 30% of approved medications target GPCRs, they interact with only a small number of them. Here, we consider whether there might be new opportunities for transformative therapeutics for neuropsychiatric disorders by specifically targeting both known and understudied...