Psychedelic-assisted therapies (PATs) can produce rapid and sustained antidepressant effects, yet variability in response remains substantial. Identifying predictors and moderators is essential for optimising patient selection, preparation, and delivery. To map and synthesise the evidence on the predictors of antidepressant response to classic/serotonergic psychedelics administered with...
The current review focused to gather the available reports whether Rajyoga meditation have an effective role for overcoming post-traumatic stress disorder (PTSD) and allied reactions in a flood situation. The purpose of this article is to analyses the flood victims’ conditions, their psychosomatic illness in Indian context followed by comparing the scenario with slum people of Arambagh Block,...
Over the past 15 years, psychedelic treatments have garnered substantial clinical interest, with psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) advancing to phase 3 trials for various psychiatric conditions. This state-of-the-art review examines the evidence for these treatments and their proposed mechanisms of action, and identifies key challenges in clinical translation. Psychedelic...
Summarizes preclinical and clinical evidence on ayahuasca—a traditional Amazonian brew combining N, N-Dimethyltryptamine (DMT) and β-carbolines—in treating depression, anxiety, post-traumatic stress disorder, substance use, eating, and personality disorders. Preclinical work shows enhanced neuroplasticity, reduced inflammation, and oxidative stress. Human neuroimaging reveals decreased default...
This thesis explores the use of ketamine in people with treatment-resistant depression. It starts by examining the concept of treatment-resistant depression, a term that is widely used but poorly defined. Importantly, this label may negatively influence patients’ expectations and sense of hope. As an alternative, more neutral framing is suggested.Survey data from individuals seeking ketamine...
Non-medical ketamine use is becoming increasingly common in the United States (US), but awareness remains limited among US healthcare providers. Here we present the case of a young woman who developed severe ketamine use disorder in the setting of an acute exacerbation of chronic post-traumatic stress disorder (PTSD). She also demonstrated symptoms concerning for two known complications of...
Interest in psychoactive substances, including psychedelics, is rapidly expanding in medical, academic, and other popular fields. Despite the classifications established within the psychopharmacological scientific community, certain plants, animals, and fungi, as well as the substances obtained from them, have been misclassified by both the media and academic circles. This opinion piece aims to...
Psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) produce rapid, enduring therapeutic effects in post-traumatic stress disorder (PTSD); however, the underlying cellular mechanisms remain incompletely understood. This study investigated whether adult myelin plasticity contributes to the therapeutic actions of psilocybin and MDMA in a rat model of contextual fear conditioning. Adult male...
Awareness during general anesthesia—the postoperative recall of sensory experiences while under anesthesia—remains among medicine’s most haunting yet underexplored phenomena. Affecting 1 to 2 in every 1,000 patients, anesthesia awareness challenges assumptions of total unconsciousness and highlights the gap between scientific understanding and lived experience. Even with proper anesthetic...
PROMOTORFebruary 2, 2026Ni Made Saithanya Gitanjali Dhevi, Rofi Bramantyo, Septy Rianty Salsabilla Dwi Putri et al.
Depression is a psychological disorder that affects aspects of affection, physiology, cognition, and individual behavior, and has an impact on significant changes in daily life. Data from the Ministry of Health of the Republic of Indonesia (2023) shows a national prevalence of depression of 1.4%, with the age group of 15-24 years recording the highest rate of 2%. One approach that is considered...