Psychedelic-assisted therapy (PAT) has demonstrated substantial efficacy across a range of mental disorders. However, heterogeneity between patients confers differential responsiveness. This systematic review aims to explore factors which may predict therapeutic responses to PAT. A systematic search was performed from inception through to March 2024 and studies that assessed predictors of...
This paper introduces the concept of egostasis (self-based goal-directed persistence behaviour) and proposes a novel neurophenomenological theory of the experience of suffering, grounded in the framework of active inference. We argue that psychological suffering is a transmodal, aversive state arising from prediction errors being attributed to a self-model. Chronic suffering is proposed to...
Mental health issues are rapidly increasing in India and around the world. Depression, anxiety, stress, insomnia—these words no longer sound alien. But when it comes to treatment, most people think only of medications and psychiatrists. This is where yoga and meditation come into play—not just as a traditional practice, but also as a scientifically proven treatment method. This chapter attempts...
The integration of psychedelics and music in therapeutic settings is gaining recognition for its potential to enhance mental health outcomes. This review synthesizes current evidence on the neurobiological mechanisms underlying this synergy, focusing on receptor-level pathways (e.g., 5-HT2A receptor agonism, BDNF-TrkB signaling) and neural circuit dynamics (e.g., default mode network...
Pediatric surgical nursing is characterized by high clinical acuity, emotional intensity, and significant occupational stressors that contribute to burnout, compassion fatigue, and workforce challenges. Mindfulness-based interventions (MBIs), including Mindfulness-Based Stress Reduction, Mindfulness-Based Cognitive Therapy, and Acceptance and Commitment Therapy, have demonstrated effectiveness...
РЕЗЮМЕ. Кетамін, відомий понад 60 років як дисоціативний анестетик, демонструє унікальний мультимодальний фармакологічний профіль, що виходить за межі класичного NMDA-антагонізму. Ця комплексна дія стала основою для його клінічної еволюції та «перевідкриття» у нових терапевтичних нішах, зокрема у психіатрії. Мета – систематизувати та проаналізувати наукові дані щодо клінічної еволюції кетаміну:...
Dear Editor, While there is a growing interest towards subconscious phenomena globally, experiences like lucid dreaming are under-researched in South Asia and remain largely unrecognized in Pakistan’s academic and clinical settings despite their widely acknowledged psychological significance. International studies have examined the association between lucid dreaming and psychopathology with...
Psychedelics a class of psychoactive compounds such as psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT) are undergoing a scientific renaissance. Studies since 2020 have shown their therapeutic promise in mental health treatment. This Commentary synthesizes historical usage, current neuroscientific and clinical evidence, and explores ethical and regulatory frontiers for...
Autism Spectrum Disorder (ASD) is a lifelong condition marked by challenges in social communication and repetitive behaviors. Current treatments, primarily behavioral therapies, often fail to address the core symptoms. Recent research has explored the potential of psychedelics, such as LSD, psilocybin, and MDMA, as a new therapeutic approach. While these substances primarily modulate the...
Esta revisión analiza cómo la suplementación con L-triptófano en el sustrato de cultivo de Psilocybe cubensis potencia la biosíntesis de psilocibina vía las enzimas PsiD, PsiH, PsiK y PsiM, alcanzando aumentos significativos en laconcentración alcaloide respecto a controles sin suplemento.La psilocibina después de ser ingerida se convierte en psilocina por un proceso de desfosforilación, que...