European Journal of Psychotraumatology
January 19, 2026
Chulei Tang, Ting Zhao, Simin Yu et al.
Background: Posttraumatic stress disorder (PTSD) is highly prevalent among people with HIV (PWH) and is associated with poor psychological functioning and reduced adherence to antiretroviral therapy (ART), threatening treatment outcomes. Although the Community Resiliency Model (CRM) and mindfulness-based stress reduction (MBSR) have separately demonstrated efficacy for PTSD, no intervention...
International Ayurvedic Medical Journal
January 19, 2026
Kushwaha Madan Mohan Singh, Gehani Leena
Chittodvega, described in Ayurvedic literature as a Vata-dominant Manasika Vyadhi, closely resembles Post-Traumatic Stress Disorder (PTSD) due to its shared features of mental agitation, fear, intrusive thoughts, irritabil-ity, and insomnia. This case study evaluates the therapeutic effect of cyclic Raj yoga meditation, Bhramari Pra-nayama, deep abdominal breathing, and Om chanting on a...
iScience
January 16, 2026
Amir Valizadeh, John D Roache, Xinyu Zhang et al.
2 citations
Post-traumatic stress disorder (PTSD) exhibits extensive clinical and biological variability, making treatment challenging. The Consortium to Alleviate PTSD (CAP)-ketamine trial, the largest randomized study of ketamine for PTSD, found no overall benefit of ketamine over placebo, underscoring the necessity to identify responsive subgroups. Using pre-treatment blood DNA methylation profiles and...
2026
Zarmeen Zahid, Brandon Weiss, Sandeep Manel Nayak
preprint
This nightmare-focused study was conducted based on data collected in an open-label, controlled treatment pilot trial conducted at the Johns Hopkins Center for Psychedelic and Consciousness Research (CPCR) under an approved protocol (IRB00407008; NCT06407635). Participants completed screening, baseline assessment, four preparatory sessions, two psilocybin dosing sessions, seven post-session...
OSF Preprints
2026
Anthony Sanchez
preprint
This project explores a translational research framework for trauma recovery and post-traumatic stress disorder (PTSD) integrating evidence from psychoplastogenic compounds, autonomic regulation, interoceptive neuroscience, affective somatosensory signaling, psychophysiology, and structured somatic intervention. The work emphasizes rigorous evidence stratification, methodological transparency,...
Contemporary Clinical Trials
2026
Christine A Rabinak, Paul E Kilgore, Mark A. Lumley et al.
Prolonged exposure (PE) therapy is effective for PTSD, yet dropout and partial response remain concerning. Preclinical and human studies suggest Δ9-tetrahydrocannabinol (THC) enhances fear extinction and recall through brain cannabinoid receptor activation in fear processing. Examine whether synthetic THC (dronabinol) augments PE effectiveness. Double-blind, placebo-controlled, trial with...
Case Reports in Psychiatry
2026
Ridhi J. Vyas, Ryan Hood, Jeremy Hsiang et al.
3,4‐Methylenedioxymethamphetamine (MDMA)‐assisted psychotherapy (MDMA‐AP) has shown promise in treating post‐traumatic stress disorder (PTSD), particularly in treatment‐resistant cases. However, little is known about its potential to precipitate adverse psychiatric outcomes. We present the case of a 31‐year‐old woman with nondistressing childhood compulsions, chronic PTSD, and complex medical...
Journal of Neuroendocrinology
2026
Hiroe Hu, Yoojin Lee, Alaina N Tillman et al.
1 citation
Arginine vasopressin (AVP) modulates stress responsivity and social-affective behaviors, but its role in mood and trauma-related disorders remains poorly defined due to challenges in peripheral measurement. This study used copeptin, a stable, reliable, and well-validated surrogate marker of AVP secretion, to assess vasopressinergic function in a transdiagnostic sample of individuals...
Psychological Medicine
2026
Ricarda Evens, Abdo Uyar, Emily Gosslau et al.
BACKGROUND: While clinical research on psychedelics often reports mild and transient side effects, broader survey studies indicate that a subset of users experiences lasting adverse mental health effects. This study investigated whether some of these meet diagnostic criteria for post-traumatic stress disorder (PTSD). METHODS: = 243) was conducted with individuals reporting distressing...
Current Treatment Options in Psychiatry
December 26, 2025
Manasicha P. Wongpaiboon, Jackson L. Shelton, Eric Delgado Rendon et al.
Purpose A systematic review was conducted to synthesize the efficacy, safety, and tolerability of psychedelics including ketamine, MDMA, ayahuasca, LSD, DMT, ibogaine, and psilocybin in the treatment of PTSD. Recent Findings Among 5,155 studies identified, 42 studies met criteria and were included in our systematic review. Ketamine consistently produced rapid symptom improvement that attenuated...