Psychoplastogens, Autonomic Regulation, and Somatic Intervention in PTSD Research
Anthony Sanchez
OSF Preprints 2026 preprint DOI: 10.17605/osf.io/jz8ca (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper |
|---|---|
| Topics | PTSD |
| Key points | Argues that a translational framework integrating psychoplastogenic compounds, autonomic regulation, interoceptive neuroscience, affective somatosensory signaling, psychophysiology, and structured somatic intervention may advance trauma recovery and PTSD research. The authors emphasize evidence stratification, methodological transparency, biomarker integration, and safety-focused design, and explicitly distinguish peer-reviewed evidence, observational findings, preclinical mechanisms, and hypothesis-generating models while not advocating premature clinical adoption. |
Abstract
This project explores a translational research framework for trauma recovery and post-traumatic stress disorder (PTSD) integrating evidence from psychoplastogenic compounds, autonomic regulation, interoceptive neuroscience, affective somatosensory signaling, psychophysiology, and structured somatic intervention. The work emphasizes rigorous evidence stratification, methodological transparency, biomarker integration, and safety-focused clinical research design. Particular attention is given to the limitations of current PTSD treatments, methodological challenges in psychedelic-assisted therapy research, autonomic and neurovisceral models of self-regulation, and the translational potential of multimodal interventions targeting neuroplasticity, embodied defensive conditioning, and physiological regulation. This repository contains evolving white paper drafts, reference materials, figures, regulatory analyses, and proposed future research directions intended for scientific and translational discussion. The project does not advocate premature clinical adoption of investigational therapies and explicitly distinguishes peer-reviewed evidence, observational findings, preclinical mechanisms, and hypothesis-generating models
Comparable studies
Other theoretical and historical papers on PTSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Theorizing that Psychedelic Assisted Therapy May Play a Role in the Treatment of Trauma-Induced Personality Disorders. | 2024 | Theoretical or philosophical paper | |
| The potential use of N-methyl-3,4-methylenedioxyamphetamine (MDMA) assisted psychotherapy in the treatment of eating disorders comorbid with PTSD. | 2021 | Theoretical or philosophical paper | |
| MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations. Adolescents with PTSD | 2024 | Theoretical or philosophical paper | |
| Agency in Post-traumatic Stress Disorder: Implications for Therapy | 2023 | Theoretical or philosophical paper | |
| The Inner World in the Outer World: The Phenomenology of Posttraumatic Stress Disorder from a Psychoanalytic Perspective | 1996 | Theoretical or philosophical paper |