Computers in Human Behavior Reports
June 16, 2026
Peng Tan, Yanpin Song, Xinyu Zhang et al.
Breathing meditation (BM), particularly when delivered via virtual reality (VR), has shown promise in reducing anxiety and stress and enhancing mindfulness. Recent evidence suggests that embedding rhythmic elements, such as temporally structured inhalation, exhalation, and breath-holding, may further regulate BM’s effectiveness. However, the specific role of rhythm in VR-based breathing...
Molecular Psychiatry
April 13, 2026
Xin Zhao, Xinyu Zhang, Shiying Yuan et al.
Ketamine, a potent N-methyl-D-aspartate receptor (NMDAR) antagonist, is widely used for anesthesia and analgesia and, because of its rapid antidepressant effects, in psychiatry. Increasing evidence suggests that ketamine and its enantiomers-(R)-ketamine (arketamine) and (S)-ketamine (esketamine)-also modulate systemic immunity and provide organ protection, partly through interactions with the...
iScience
January 16, 2026
Amir Valizadeh, John D Roache, Xinyu Zhang et al.
2 citations
Post-traumatic stress disorder (PTSD) exhibits extensive clinical and biological variability, making treatment challenging. The Consortium to Alleviate PTSD (CAP)-ketamine trial, the largest randomized study of ketamine for PTSD, found no overall benefit of ketamine over placebo, underscoring the necessity to identify responsive subgroups. Using pre-treatment blood DNA methylation profiles and...
Journal of Neuroinflammation
December 18, 2025
Mengqi Han, Bing Xie, Yuan Yu et al.
Chronic stress precipitates depression, yet how gut-immune-brain interactions translate stress into mood pathology remains unclear. We tested the hypothesis that stress-primed small intestinal γδ T cells drive hippocampal mitochondrial dysfunction and depression-like behavior via interleukin-17A (IL-1A). In mice exposed to chronic restraint stress (CRS), we combined behavioral assays...
Current biology : CB
February 3, 2025
Shuai Chang, Xinyu Zhang, Yangjianyi Cao et al.
Activity in the early visual cortex is thought to tightly couple with conscious experience, including feedback-driven mental imagery. However, in aphantasia (a complete lack of visual imagery), the state of mental imagery, what takes its place, or how any activity relates to qualia remains unknown. This study analyzed univariate (amplitude) and multivariate (decoding)...