Abstract Psychedelic therapy has the potential to become a revolutionary and transdiagnostic mental health treatment, yielding enduring benefits that are often attributed to the experiences that coincide with peak psychedelic effects. However, there may be an underrecognized temporal structure to this process that helps explain why psychedelic and related altered states of consciousness can...
The rapidly evolving psychedelic industry has garnered considerable attention due to 3,4-methylenedioxymethamphetamine-assisted psychotherapy's ground-breaking success in treating moderate-to-severe Post-traumatic Stress Disorder in two Phase 3 clinical trials. This has opened Pandora's box for the development of innovative therapeutic modalities. Of particular interest are the phenethylamines...
Zusammenfassung Seit den späten 1990er-Jahren erfahren Psychedelika eine Renaissance und ziehen international vermehrt die Aufmerksamkeit auf sich. Es gibt zunehmend wissenschaftliche Studien, die sich mit den Möglichkeiten und Risiken der Psychedelika-assistierten Therapie (PAT) befassen. Seit 2014 werden auf der Grundlage von Ausnahmebewilligungen der Schweizer Gesundheitsbehörde (Bundesamt...
The neurobiological mechanisms underpinning psychiatric disorders such as treatment-resistant major depression, post-traumatic stress disorder, and substance use disorders, remain unknown. Psychedelic compounds, such as psilocybin, lysergic acid diethylamide, and N,N-dimethyltryptamine, have emerged as potential therapies for these disorders because of their hypothesized ability to induce...
Introduction Psilocybin is a classic psychedelics, which has been shown to have antidepressant effects by many studies in recent years. In this study, we aim to evaluate the efficacy, acceptability and tolerability of psilocybin in the treatment of primary (major depressive disorder) or secondary (experiencing distress related to life-threatening diagnoses and terminal illness) depression....
Patients with serious illnesses like advanced cancer often experience existential and psychospiritual distress. Alleviating this form of pain and suffering has proven to be very challenging using conventional treatments. Psilocybin-assisted therapy (PAT) employs the psychoactive effects of psilocybin as a catalyst for a psychotherapeutic process grounded in indigenous traditions and within the...
This paper examines the potential of group psychedelic therapies in addressing suicidality, particularly in the context of social disconnectedness. With suicide recognised as a complex issue influenced by multiple factors, including a lack of social connectedness, this research explores the use of psychedelics in group settings as a novel approach to enhance social connectedness and potentially...
Zusammenfassung Hintergrund In den letzten Jahren wurde die klinische Forschung zu Psychedelika-gestützter Therapie psychischer Störungen wieder aufgenommen, mit einer stetig steigenden Zahl von Studien und Publikationen. Dabei sind viele ethische Fragen aufgekommen, die noch nicht ausreichend untersucht und beantwortet wurden. Ziel Dieser Beitrag gibt einen Überblick zum Stand der klinischen...
There has been renewed interest in the use of 3,4-methylenedioxy-methamphetamine (MDMA) and serotonergic psychedelics in the treatment of multiple psychiatric disorders. Many of these compounds are known to produce prosocial effects, but how these effects relate to therapeutic efficacy and the extent to which prosocial effects are unique to a particular drug class is unknown. In this article,...
Zusammenfassung Erste Studienergebnisse zeigen ein Potenzial von Psychedelika und 3,4-Methylendioxy-N-methylamphetamin (MDMA) für die Behandlung von affektiven Störungen. Im vorliegenden Beitrag wird argumentiert, dass die Ausbildung von Therapeut*innen von entscheidender Bedeutung ist, um diese Substanzen in der Psychedelika-assistierten Therapie (PAT) sicher und wirksam einzusetzen....