Acta neurológica colombiana
August 26, 2025
Gianfranco Faccini-Durán
Introducción: la psilocibina, un alcaloide triptamínico presente en hongos genero psilocybe, actúa uniéndose a receptores serotoninérgicos de tipo 2A (5HT2A), activando respuestas metabotrópicas y resultando en procesos de neuroplasticidad. Se integran diversas metodologías de abordaje científico, incluyendo estudios pre clínicos y clínicos, sobre con los efectos neurofisiológicos, y el...
Molecular Psychiatry
August 26, 2025
Ross J. Purple, Rahul Gupta, Christopher W. Thomas et al.
2 citations
Abstract We quantify cellular- and circuit-resolution neural network dynamics following therapeutically relevant doses of the psychedelic psilocybin. Using chronically implanted Neuropixels probes, we recorded local field potentials (LFP) alongside action potentials from hundreds of neurons spanning infralimbic, prelimbic and cingulate subregions of the medial prefrontal cortex of...
Research Square
August 21, 2025
Ritchy Hodebourg, Lillian Duncan, Eric Dereschewitz et al.
preprint
The rising legal acceptance of cannabis and the high comorbidity between cannabis use disorder (CUD) and post-traumatic stress disorder (PTSD) highlight the importance of understanding how stress and cannabis influence the brain. We recently discovered that cannabis use promotes two PTSD-like symptoms: avoidance coping behaviors and the generalization of stress-coping responses to a neutral...
Brain Sciences
August 21, 2025
Dean Bilenker, Nicole M. Avena
2 citations
Recent advances in psychedelic research have renewed interest in their therapeutic potential for psychiatric disorders characterized by cognitive and behavioral rigidity. This review examines the rationale for using serotonergic psychedelics—particularly 5-HT2A receptor agonists such as psilocybin—in the treatment of eating disorders (EDs), including anorexia nervosa (AN), bulimia nervosa (BN),...
Trends in Cognitive Sciences
August 18, 2025
Flora Moujaes, Nathalie M. Rieser, L. Belinger et al.
5 citations
Serotonergic psychedelics are being explored as treatments for a range of psychiatric conditions. Promising results in mood disorders indicate that their effects on emotional processing may play a central role in their therapeutic potential. However, mechanistic and clinical studies paint a complex picture of the impact of psychedelics on emotions and mood. Here, we review recent findings on...
Journal of Psychology and Behavioral Science
August 16, 2025
Amira Arora
This review critically examines how meditation, particularly mindfulness-based practices, contributes to habit change through mechanisms grounded in behavioral science. Drawing on dual-process theories, reinforcement learning, and self-regulation models, the paper explores how meditation enhances meta- awareness, disrupts automatic behavioral loops, and facilitates intentional change....
Brazilian Journal of Implantology and Health Sciences
August 14, 2025
A. Silva, Érika Barros Teixeira da Cruz, Samuel Cândido Freres et al.
O transtorno de estresse pós-traumático (TEPT) é uma condição psiquiátrica caracterizada por sintomas persistentes após vivência de eventos traumáticos, incluindo revivescências, hipervigilância e esquiva. Estudos recentes têm apontado o uso de psicodélicos, como MDMA e psilocibina, como potenciais coadjuvantes no tratamento, devido à sua capacidade de promover neuroplasticidade e facilitar a...
Journal of Psychedelic Studies
August 13, 2025
Michael J. Winkelman
This paper examines possible future evolution through knowledge of how past human evolution constrains possibilities for the future. Uniquely human evolution-brain, ultrasociality, and cultural niche development-are examined to see what these suggest about future adaptations. Rapid brain evolution involves neuroplasticity, a re-use and rewiring of neural networks. Psychedelics are extraordinary...
psychopraxis neuropraxis
August 11, 2025
Arif de Mendelssohn, Henriette Löffler-stastka
Zusammenfassung Serotonin (5-HT) ist ein fundamentaler Neuromodulator, dessen komplexe Rolle in der Psychiatrie oft auf vereinfachte Modelle wie die „Chemische-Dysbalance-Hypothese“ reduziert wurde. Ein zeitgemäßes Verständnis von höherem heuristischen Wert erfordert demgegenüber die Integration verschiedener wissenschaftlicher Ansätze. Dieser Artikel synthetisiert die Theorien von Mark Solms...
Neuropsychiatric Disease and Treatment
August 9, 2025
Qing-Mei Li, Shuming Liu, Bangyong Qin et al.
Abstract This review systematically summarizes the research progress of ketamine and its interaction with specific brain regions in the context of neuropathic pain comorbid with depression. As a non-competitive inhibitor of N-methyl-D-aspartate (NMDA) receptors, Ketamine exerts complex mechanisms and controversial topic. The structure and function of NMDA receptors, as well as the binding sites...