ACS Chemical Neuroscience
October 13, 2025
Rajiv Agrawal, Daniel J. Gillie, Alison E. Mungenast et al.
8 citations
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid and enduring therapeutic effects of psychedelics and the dissociative anesthetic ketamine. However, safety concerns related to hallucinogenic/dissociative properties have limited the addressable...
PROCEEDINGS OF THE SLIIT INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN SCIENCES AND HUMANITIES [SICASH]
October 10, 2025
Renee Ireland
Psychedelic-assisted therapies are re-emerging as credible options in psychological care amid a high global burden of mental ill-health and limited response to first-line treatments. Once marginal, psychedelics are now part of mainstream research and policy debate, while remaining illegal or tightly restricted in many jurisdictions. Classic and atypical compounds (e.g., psilocybin, MDMA) act...
ACS Medicinal Chemistry Letters
October 10, 2025
Anna C. Renner, Robert B. Kargbo
A crystalline cocrystal of psilocin and psilocybin enhances exposure, neuroplasticity biomarkers, and functional activity, while adjunctive atypical antipsychotics modulate serotonergic signaling to mitigate 5-HT2B-linked safety concerns. Together, these inventions advance formulation, mechanistic selectivity, and translational biomarkersoffering a chemistry-enabled path to scalable...
Journal of Mental Health and Psychiatry
October 9, 2025
Angelika Wagner
This article explores the relationship between meditation, prayer, neuroscience, and the pursuit of inner and global peace through the perspectives of Pope Leo XIII and contemporary neuroscience. Drawing on clinical, educational, and trauma-informed experiences, the author examines how practices such as meditation, prayer, breathwork, and contemplative reflection can promote emotional...
ACS Medicinal Chemistry Letters
October 9, 2025
Anna C. Renner, Robert B. Kargbo
Recent patents disclose complementary strategies to optimize psychedelic-assisted therapy. Novel psilocin prodrugs improve pharmacokinetics and stability, while digital systems enable cognitive state monitoring during treatment. Parallel advances in combining neuroplastogen drugs with transcranial electrical stimulation highlight a model-driven approach to enhance and personalize neural...
Revista fisio&terapia
October 8, 2025
Maurício Pedro Luciano da Costa, Pedro Bruschi Peiretti, Pedro Vinicius Rodrigues Silveira Silva et al.
A resurgence of scientific and clinical interest in psychedelic-assisted therapies, particularly with Psilocybin, has been observed. This paper presents an integrative literature review aiming to identify the scientific contributions, potential benefits, and limitations of the therapeutic use of psilocybin in mental health. The study followed a rigorous protocol. Searches were conducted in the...
Revista de Arqueología Americana
October 6, 2025
Jacob Keer, Justin Jennings
Although archaeologists increasingly consider the roles of psychedelics in past societies, there is little attention paid to their longer-term psychological impacts. One of these impacts is a neuroplasticity that may elicit enduring pro-social feelings. A beer laced with the psychedelic Anadenanthera colubrina (also known as vilca) was regularly consumed at feasts during the Wari Empire of...
Neuroscience & Biobehavioral Reviews
October 1, 2025
Peter Jedlicka, Martha Nari Havenith
3 citations
The emergence of spiritual and religious practices can be seen as a major cognitive transition in the evolution of biological organisms. Spiritual and religious experiences are closely linked to evolved complex brain structures, as well as their dynamics and plasticity. In this review, we will focus on the neural mechanisms that make such experiences possible. We will also address the...
Cureus
October 1, 2025
Abdelazim Ali, Nahida Ahmed, Sona Varghese
Major depressive disorder (MDD) frequently co-occurs with substance use disorders (SUDs), leading to poorer outcomes and limited options. Esketamine is approved for treatment-resistant depression (TRD); its effects on craving and abstinence in SUD are less explored. A 41-year-old man with recurrent MDD (suicidal ideation) and polysubstance use (daily morphine/prescription opioids; intermittent...
Research Journal of Pharmacy and Technology
October 1, 2025
Raj Nashikkar, Shrikrishna Baokar, Rajendra Patil
Ayahuasca is a traditional hallucinogenic concoction utilised by indigenous populations in the Amazon Basin for ages in spiritual and therapeutic rituals. The increasing global popularity is attributed to its alleged medicinal and consciousness-expanding properties. The infusion is primarily composed of two key components: the Banisteriopsis caapi vine and the leaves of Psychotria viridis,...