Ten years ago, we published a position paper in this journal, criticizing reductionist claims of neurobiology related to mental disorders and important theoretical concepts like free will. Our interdisciplinary group of experts highlighted the need for and the challenges of integrating different approaches and system levels in neuroscience. We argued-and still argue-that such an integrative and...
The history of mental science is marked by a divide between the subjective, energetic models of psychoanalysis and the objective models of computational neuroscience. Reductionist approaches often fail to bridge this gap or adequately explain the structural complexity of psychopathology. This conceptual synthesis aims to propose a unified, testable neurocomputational framework anchored in the...
Zusammenfassung Serotonin (5-HT) ist ein fundamentaler Neuromodulator, dessen komplexe Rolle in der Psychiatrie oft auf vereinfachte Modelle wie die „Chemische-Dysbalance-Hypothese“ reduziert wurde. Ein zeitgemäßes Verständnis von höherem heuristischen Wert erfordert demgegenüber die Integration verschiedener wissenschaftlicher Ansätze. Dieser Artikel synthetisiert die Theorien von Mark Solms...
Depression has been widely studied by researchers from different fields, but its causes, and mechanism of action are still not clear. A difficulty emerges from the shifting from objective diagnosis or analysis to exploration of subjective feelings and experiences that influence the individuals' expression, communication and coping in facing depression. The integration of the experiential...
Objective: N-(2-methoxy) benzyl-phenethylamine (NBOMe) derivatives have a high affinity to the serotonin receptor 2A and emerged as new psychedelic agents. We report the case of a 30-year-old man admitted to the hospital because of acute ischemia of the left arm with clinical symptoms of pallor, pulselessness, paresthesia, and a motoric deficit. The patient had a history of schizophrenia and...