Neuroplasticity: all studies (page 85) - The Consciousness Library

Stereoselective, sex-dependent 5-HT2A receptor modulation of cortical plasticity by MDMA in mice.

Neuropsychopharmacology February 2, 2026 Maya C Gaines-Smith, Justin M Silverman, Michael Fiorillo et al. 3 citations

The psychoactive entactogen 3,4-methylenedioxymethamphetamine (MDMA), widely known as a recreational drug, is gaining renewed attention as a potential psychotherapeutic adjunct for treatment-resistant psychiatric disorders, yet its neurobiological mechanisms - particularly those related to its stereoisomers and sex-specific effects - remain poorly understood. Here, we report stereoselective and...

DOI: 10.1038/s41386-025-02313-x Full text

Administration of the Synthetic Cannabinoid WIN55,212-2 Increases BDNF Expression Levels in the Adolescent Rat Brain.

Cannabis and Cannabinoid Research February 1, 2026 Alejandro Guadalupe Torres, Jordan Santos, Dolores Vazquez Sanroman

The increase in cannabinoid use among adolescents has become a public health concern in North America, with more than one-third of 12th graders in the United States reporting consumption of some form of cannabis within the past year (2023).1,2 The use of cannabinoids during adolescence, a vulnerable stage for brain development, may alter the neuroplasticity dependent on brain-derived...

DOI: 10.1177/25785125251410807 Full text Bdnf Win55-212-2 Adolescence Cannabinoids +2

The hippocampus as a central hub in ketamine's antidepressant action: from molecules to circuit rewiring.

Neuropsychopharmacology February 1, 2026 Dongsun Park, Gwangho Lee, Bokyum Kim et al. 1 citation

Ketamine has emerged as a rapid-acting antidepressant that challenges classical monoaminergic frameworks and highlights the importance of synaptic and circuit-level plasticity in mood regulation. This review examines the hippocampus as a key site through which ketamine exerts both rapid and sustained antidepressant effects. We synthesize evidence showing that ketamine enhances hippocampal...

DOI: 10.1038/s41386-025-02288-9 Full text

A retrospective report of a ketamine-augmented, transdiagnostic psychiatric outpatient psychotherapy program

Journal of Military, Veteran and Family Health February 1, 2026 Ian Stefanuk, Kaitlin Chivers-Wilson, Rakesh Jetly et al.

Introduction: Comorbid conditions such as major depressive disorder, anxiety disorders, and posttraumatic stress disorder are common among Veterans, and the presence of multiple conditions requires innovative treatment approaches. The Newly Institute in Calgary, Alberta, Canada, has introduced a novel intervention combining sublingual ketamine therapy with a medically managed transdiagnostic...

DOI: 10.3138/jmvfh-2025-0009 Anxiety disorder Checklist Depression economics Intervention counseling +7

Repeated administration of the synthetic cannabinoid AKB48 induces serotonergic neuroadaptation in male and female mice: behavioural and immunohistochemical evidence.

Neuropharmacology February 1, 2026 Giorgia Corli, Fabrizio De Luca, Sabrine Bilel et al. 1 citation

In the last years, Synthetic Cannabinoids (SCBs) have established themselves as one of the largest and most popular groups of Novel Psychoactive Substances (NPS), being frequently detected in biological samples of patients involved in intoxication and death cases. To date, compelling evidence on the potential interaction between SCBs and non-cannabinoid neurotransmission systems has emerged,...

DOI: 10.1016/j.neuropharm.2025.110758 Full text 25i-nbome pubchem cid 2c-i pubchem cid 5-ht2a receptors Akb48 pubchem cid +5

The Emerging Crisis in Non-Prescribed Ketamine Use: A Rapid Attenuation of Depression in Face of Abuse and "Chill-out" or Escapism Drug.

Substance Use & Misuse February 1, 2026 Kai-Uwe Lewandrowski, Kenneth Blum, Sergio Schmidt et al.

Since 2000, rates of suicide and opioid overdose have sharply increased. Approximately one-third of individuals with major depressive disorder (MDD) experience treatment-resistant depression (TRD), highlighting the urgent need for novel therapeutic approaches. This review synthesizes pivotal preclinical and clinical findings on low-dose ketamine's rapid antidepressant effects and examines...

DOI: 10.1080/10826084.2025.2612330 Full text Ketamine Dopamine Rapid antidepressant effect

Accelerated recovery using magnesium ibogaine: characterizing the subjective experience of its rapid healing from neuropsychiatric disorders.

npj Mental Health Research January 31, 2026 Clayton Olash, Derrick Matthew Buchanan, Randi Brown et al. 1 citation

Magnesium-ibogaine, a formulation combining ibogaine with pre- and post-treatment magnesium, was recently found to yield rapid clinical improvements in U.S. Special Operations veterans with TBI and PTSD. Yet, its therapeutic phenomenology during such healing is unknown. We analyzed post-session narratives from 30 male veterans who, after a single open-label magnesium-ibogaine treatment,...

DOI: 10.1038/s44184-026-00185-7 Full text

Hypnosis as a Mechanism of Emotion Regulation and Self-Integration: Neural, Cognitive, and Experiential Pathways to Fundamental Peace

Preprints.org January 30, 2026 Luis Miguel Gallardo, Saamdu Chetri preprint

Hypnosis has traditionally been conceptualized as a clinical technique for symptom reduction, yet emerging neuroscience evidence suggests it functions more fundamentally as a mechanism of emotion regulation and self-integration. This integrative review synthesizes research from cognitive neuroscience, affective science, and clinical hypnosis to examine how hypnotic states modulate large-scale...

DOI: 10.20944/preprints202601.2336.v1 Default mode network Mindfulness Mechanism biology Operationalization +14

PSILOCYBIN IN PSYCHIATRIC PRACTICE AND PSYCHEDELIC-ASSISTED THERAPY FOR TREATMENT-RESISTANT DEPRESSION

International Journal of Innovative Technologies in Social Science January 28, 2026 Łukasz Deska, Cezary Kosmecki, Dawid Głaz et al.

This manuscript comprehensively reviews psilocybin-assisted therapy for major depressive disorder and treatment-resistant depression. It aims to synthesize current understanding regarding its mechanisms, efficacy, safety, costs, and accessibility, comparing it with conventional antidepressant and ketamine treatments. The methodology involved a narrative synthesis of academic literature, drawing...

DOI: 10.31435/ijitss.1(49).2026.4711 Psilocybin Major depressive disorder Treatment-resistant depression Ketamine +9

Qualia as Reinforcement Signatures: How Neural Learning History Shapes Phenomenal Character

Zenodo (CERN European Organization for Nuclear Research) January 25, 2026 Heng Liu preprint

This paper proposes a radically new theory of phenomenal qualities (qualia): they are not intrinsic properties of sensory states but individualized signatures created by neural reinforcement learning history. The phenomenal character of experiencing red, sweet, or pain emerges from integrating current sensory input with an organism's unique history of reward associations, punishment...

DOI: 10.5281/zenodo.18367500