Autism Spectrum Disorder (ASD) is a neurodevelopmental condition marked by persistent social communication deficits and repetitive behaviors, with communication abilities ranging from nonverbal to verbally fluent yet socially impaired. These deficits, linked to disrupted neural connectivity in regions like the posterior superior temporal sulcus (pSTS), reward circuits, and dorsal/ventral speech...
Understanding consciousness, cognition, and behaviour requires an integrated framework capable of bridging neurobiology, physics, and information theory. In this paper, we propose the Energy-Mass-Information (EMI) framework as a novel paradigm to conceptualize mental phenomena as emergent properties of dynamic, field-based interactions. Rooted in, and direct expression of the Unified...
This project explores a translational research framework for trauma recovery and post-traumatic stress disorder (PTSD) integrating evidence from psychoplastogenic compounds, autonomic regulation, interoceptive neuroscience, affective somatosensory signaling, psychophysiology, and structured somatic intervention. The work emphasizes rigorous evidence stratification, methodological transparency,...
Beyond its antidepressant effects, esketamine (ESK) has the potential to enhance neuroplasticity, facilitating the reconnection with emotional and cognitive processes, improving social cognition, and promoting resilience. However, not much is known about its role in Alzheimer's disease (AD). This study aims to explore the potential mechanism of ESK in AD treatment. The potential targets of ESK...
Despite the dramatic growth in the number of clinical trials of meditation and/or mindfulness-based interventions (MMBIs), most trials focus on self-reported or psychological outcomes, less is known about the potential neuroplastic effects of MMBI practice and benefits for brain health. In this review, we aimed to map the extent and nature of existing research on this topic, identify...
Major depressive disorder (MDD) is a leading cause of disability worldwide, with nearly one-third remaining treatment-resistant. Chronic stress is a major risk factor for MDD, whereas acute stress is adaptive and mediated by hypothalamic-pituitary-adrenal axis activation. Ketamine produces rapid antidepressant effects, partly through mammalian target of rapamycin complex 1 (mTORC1) signalling,...
Treatment-resistant depression (TRD) affects about 30% of patients with major depressive disorder and remains a major clinical challenge.The limited effectiveness of classical antidepressants suggests that the pathophysiology of TRD is complex and extends beyond the traditional monoamine hypothesis.The aim of this paper was to present current concepts of the neurobiological background of TRD...
Yoga-based practices have been increasingly studied as neurocognitive and psychophysiological interventions capable of modulating brain function and emotional regulation. The proposed framework integrates insights from neuroscience, cognitive psychology, and contemplative traditions to explain how yoga promotes self-regulation and cognitive flexibility. Yoga involves a dynamic interaction...
The subacute period following the use of classic psychedelics is often marked by an "afterglow" - a state characterized by elevated mood; enhanced psychological well-being; increased emotional openness toward self, others, and nature; and sometimes a heightened sense of clarity and existential meaning. From a neurobiological perspective, subacute psychedelic states have been associated with...
Aesthetic experiences are bodily-anchored, posited to evoke profound emotional responses and advance development, mental health and well-being. This paper reviews and conceptually analyzes the embodied aesthetic experience and its imperative contribution to the psychotherapeutic relational field, by integratively and interdisciplinarity interweaving neuroscientific and psychodynamic approaches...