Neuroscience
January 9, 2025
Alireza Mohammad Hosseini, Hossein Khaleghzadeh-Ahangar, Atena Rahimi
Dementia is an increasing disorder, and Alzheimer's disease (AD) is the cause of 60% of all dementia cases. Despite all efforts, there is no cure for stopping dementia progression. Recent studies reported potential effects of psychedelics on neuroinflammation during AD. Psychedelics by 5HT2AR activation can reduce proinflammatory cytokine levels (TNF-α, IL-6) and inhibit neuroinflammation. In...
bioRxiv (Cold Spring Harbor Laboratory)
January 8, 2025
Delong Zhou, Heike Schuler, Vedrana Cvetkovska et al.
2 citations
preprint
Abstract Despite enormous interest in psychedelics for psychiatric interventions, potential underlying biological mechanisms remain unclear. Here, we confirm that a single dose of psilocybin increases synaptic transmission in mouse medial prefrontal cortex. Using scRNA-sequencing, we identify cell-type specific mechanisms of sustained neuroplastic effects. We show that, 24h post-psilocybin,...
Frontiers in Human Neuroscience
January 6, 2025
Daniel Yochai Panitz, Avi Mendelsohn, Joana Cabral et al.
5 citations
Interest has been growing in the use of mindfulness meditation (MM) as a therapeutic practice, as accumulating evidence highlights its potential to effectively address a range of mental conditions. While many fMRI studies focused on neural activation and functional connectivity during meditation, the impact of long-term MM practice on spontaneous brain activity, and on the expression of resting...
Sub-cellular biochemistry
2025
Sabrina Venditti
Epigenetic mechanisms are key processes that constantly reshape genome activity carrying out physiological responses to environmental stimuli. Such mechanisms regulate gene activity without modifying the DNA sequence, providing real-time adaptation to changing environmental conditions. Both favorable and unfavorable lifestyles have been shown to influence body and brain by means of epigenetics,...
Frontiers in Psychiatry
2025
Aslihan Uyar, Ali Saffet Gonul
Major depressive disorder (MDD) presents a significant global health challenge, characterized by a high prevalence and significant impact on quality of life. Traditional antidepressants fall short in terms of efficacy and onset speed, up to 60% of patients. This review delves into the new and emerging pharmacologic treatments for MDD, focusing on their mechanisms of action, clinical...
Progress in Brain Research
2025
Nethmini Navoda Sirimanne, Nupur Dahiya, Garbis Papazian et al.
1 citation
The global rise in age-related neuropsychiatric disorders, including depression, anxiety, mild cognitive impairment (MCI), and dementia, significantly impacts healthcare systems and quality of life. Mindfulness and meditation (MM), rooted in ancient philosophical traditions, are gaining attention as promising non-pharmacological treatments. This chapter examines the historical evolution,...
Frontiers in Neuroscience
2025
Antonio Inserra, Colin J. Murray, Antonella Campanale et al.
Emerging evidence indicates that rapid-acting antidepressants (RAADs)-including ketamine and serotonergic psychedelics- may affect myelin homeostasis, aside from producing fast-onset, sustained improvements in several psychiatric disorders. A systematic search of PubMed (MEDLINE), Web of Science, Europe PMC, Directory of Open Access Journals (DOAJ), and Google Scholar was conducted up to...
University of Michigan Library
2025
Nicholas Kolbman
Psilocybin containing mushrooms have been utilized for ceremonial, medicinal, and spiritual purposes for millennia. Recently there has been a surge of scientific interest in the therapeutic potential and mechanistic understanding of serotonergic psychedelics, including psilocybin. Psilocybin is classified as a serotonergic psychedelic because the non-ordinary state of consciousness that it...
Computational and Structural Biotechnology Journal
2025
Álex Escolà-Gascón
10 citations
What if quantum entanglement could accelerate learning by unlocking higher states of conscious experience? This study provides empirical and statistical evidence of how quantum entanglement influences consciousness at a biophysical level. We analyzed data from 106 monozygotic twin pairs (N = 212), randomly assigned to control and experimental groups. Using a consanguinity-based matching...
Frontiers in Psychology
2025
Qi Mao, Wolfgang Mastnak, Ruiyuan Guan
2 citations
Archaeological findings witness the anthropological roots of dance, while psychological, medical, cultural and aesthetic studies shed light on health promoting capacities and curative factors inhering in symbolic and expressive body movement. Since dance therapy became a multifaceted discipline in the middle of the 20th century, increasing evidence of beneficial effects has advocated the use of...