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Antonella Campanale

4 papers in the library · 81 citations · publishing 2022-2025

Papers

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Potential molecular pathways and therapeutic implications of rapid-acting antidepressants on myelin biology: a scoping review.

Frontiers in Neuroscience 2025 Antonio Inserra, Colin J. Murray, Antonella Campanale et al.

Emerging evidence indicates that rapid-acting antidepressants (RAADs)-including ketamine and serotonergic psychedelics- may affect myelin homeostasis, aside from producing fast-onset, sustained improvements in several psychiatric disorders. A systematic search of PubMed (MEDLINE), Web of Science, Europe PMC, Directory of Open Access Journals (DOAJ), and Google Scholar was conducted up to...

DOI: 10.3389/fnins.2025.1690318 (opens in new tab) Full text (opens in new tab) Ketamine Neuroplasticity Neuronal activity-dependent myelination Oligodendrocytes +1

Epigenetic mechanisms of rapid-acting antidepressants

Translational Psychiatry September 4, 2024 Antonio Inserra, Antonella Campanale, Tamim Rezai et al. 24 citations

BACKGROUND: Rapid-acting antidepressants (RAADs), including dissociative anesthetics, psychedelics, and empathogens, elicit rapid and sustained therapeutic improvements in psychiatric disorders by purportedly modulating neuroplasticity, neurotransmission, and immunity. These outcomes may be mediated by, or result in, an acute and/or sustained entrainment of epigenetic processes, which remodel...

DOI: 10.1038/s41398-024-03055-y (opens in new tab) Full text (opens in new tab) Epigenetics Psychopharmacology Schizophrenia object-oriented programming Bioinformatics

Therapeutic modulation of the kynurenine pathway in severe mental illness and comorbidities: A potential role for serotonergic psychedelics.

Progress in neuro-psychopharmacology & biological psychiatry August 30, 2024 Antonella Campanale, Antonio Inserra, Stefano Comai 18 citations

Mounting evidence points towards a crucial role of the kynurenine pathway (KP) in the altered gut-brain axis (GBA) balance in severe mental illness (SMI, namely depression, bipolar disorder, and schizophrenia) and cardiometabolic comorbidities. Preliminary evidence shows that serotonergic psychedelics and their analogues may hold therapeutic potential in addressing the altered KP in the...

DOI: 10.1016/j.pnpbp.2024.111058 (opens in new tab) Full text (opens in new tab) Gut-brain axis Kynurenine pathway Serotonergic psychedelics Severe mental illness

Modulation of DNA methylation and protein expression in the prefrontal cortex by repeated administration of D-lysergic acid diethylamide (LSD): Impact on neurotropic, neurotrophic, and neuroplasticity signaling

Progress in Neuro-psychopharmacology and Biological Psychiatry June 28, 2022 Antonio Inserra, Antonella Campanale, David Cheishvili et al. 39 citations

AimPsychedelic compounds elicit relief from mental disorders. However, the underpinnings of therapeutic improvement remain poorly understood. Here, we investigated the effects of repeated lysergic acid diethylamide (LSD) on whole-genome DNA methylation and protein expression in the mouse prefrontal cortex (PFC).MethodsWhole genome bisulphite sequencing (WGBS) and proteomics profiling of the...

DOI: 10.1016/j.pnpbp.2022.110594 (opens in new tab) Neuroplasticity Prefrontal cortex Modulation music Cell biology +4