Non-selective NMDA receptor antagonism produces rapid symptom improvement in treatment-resistant depression; however, associated side effects necessitate medical oversight during administration. We hypothesised that selective GluN2A antagonism could provide similar efficacy with an improved side effect profile. Here, we report the pharmacology of JNJ-78911118, a brain-penetrant, GluN2A...
Quality in SportMay 12, 2025Izabela Zajkowska, Patrycja Niczyporuk, Aleksandra Giba et al.1 citation
This review explores an innovative, integrative therapeutic approach that combines probiotics, prebiotics, and mindfulness-based interventions (MBIs) to target the dysregulation of the gut–brain axis in schizophrenia. The rationale for this combined strategy is rooted in the overlapping mechanisms by which both biological and psychosocial interventions influence neurophysiological processes....
A presente tese foi dividia em dois capítulos. Capítulo I. Esse capítulo tem como objetivo investigar o possível potencial de reforço induzido pela ayahuasca por meio do paradigma de preferência condicionada por lugar (conditioned place preference, CPP), bem como avaliar se a ayahuasca é capaz de modular a CPP induzida pela cocaína durante as fases de aquisição, expressão e reinstalação da CPP...
Abstract Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed chronic electrophysiological recordings from the neocortex concomitant with pupillometry in freely moving adult male mice following an injection of a...
Brain InjuryMay 5, 2025Vibeke Wagner, Jakob Rud Sørensen, Christina Kruuse et al.3 citations
Early out-of-bed mobilization is recommended for individuals with severe acquired brain injury and impaired consciousness to promote recovery. Robot-assisted gait training (RAGT) utilizes robotic assistance to facilitate neuroplastic changes through repetitive training and feedback. We aimed to map the evidence of RAGT in non-ambulatory individuals with impaired consciousness or cognitive...
ABSTRACT Background Alcohol Use Disorder (AUD) is a widespread condition with serious health, social, and economic impacts, often marked by relapse despite the availability of FDA-approved treatments. Recent studies suggest that psychedelic substances, such as psilocybin, Lysergic acid diethylamide (LSD), ayahuasca, etc. may offer novel therapeutic potential in treating AUD by modulating...
Pharmacological management of major depressive disorder has traditionally relied on antidepressants targeting the monoaminergic pathway. Treatment-resistant depression (TRD) patients have been frequently excluded from registrational trials, resulting in a lack of clear clinical recommendations for an optimised management. In recent years, treatments based on other mechanisms of action have been...
May 1, 2025Jessi Humphreys, Lou Lukas, Yvan Beaussant et al.
Abstract Psilocybin, a naturally occurring psychoactive compound found in more than 200 mushroom species, has an enduring history of use in sacred rituals of Indigenous healers worldwide. With selective serotonin receptor binding, activation of the serotonergic neurological system enables psilocybin to potentiate neuroplasticity, enabling individuals to engage in meaning-making from psychedelic...
Depression is a common and serious psychiatric disorder with significant impacts on individuals. Modified electroconvulsive therapy (MECT) is an established treatment for severe and treatment-resistant depression, but its cognitive side effects, particularly memory impairments, limit its use. Esketamine (ESK), an FDA-approved antidepressant, has shown neuroprotective effects. However, its role...
Suicidal thoughts and behaviors represent a transdiagnostic dimension independent of traditional psychiatric diagnoses. This specificity is supported by genetic studies, biomarkers, and preclinical research on endophenotypes associated with suicidal behaviors, such as impulsivity, anhedonia, and hopelessness. Clear mechanisms involving inflammation, the stress response, the serotonergic system,...