Journal of Education, Health and Sport
April 5, 2025
Joanna Dmochowska, Marcin Ciechański, Joanna Cieszkowska et al.
1 citation
Introduction: Depression, affecting 350 million people globally, is a leading cause of disability. Common symptoms include low mood, sadness, guilt, anxiety, and suicidalthoughts. Current treatments, mostly monoamine-based antidepressants, have limitations such as delayed effects and low efficacy, with over 60% of patients not achieving lasting remission. Ketamine, an NMDA antagonist, has shown...
International Journal of Science and Research (IJSR)
April 3, 2025
David Nisenboim
Medical treatment for behavioral disorders such as anxiety, depression, and post-traumatic stress disorder (PTSD) represent emerging challenges in the field and have been a subject of studies for a long time. Available therapeutics include selective serotonin reuptake inhibitors (SSRIs), Monoamine oxidase inhibitors (MAOIs), tricyclics, etc. Nevertheless, recent studies have identified a...
Nature
April 2, 2025
Psilocybin, a classic psychedelic, has therapeutic potential for psychiatric disorders. A specific brain circuit and receptor have now been found to be required for psilocybin’s long-term effects on neural plasticity and depression-related behaviour. The psychedelic psilocybin’s beneficial behavioural action depends on the activation of pyramidal-tract neurons in the frontal cortex.
Asian Journal of Psychiatry
April 1, 2025
Nathan Menke, Elizabeth Hoffman, Kelsey Gaylor et al.
4 citations
Ketamine's unique pharmacological profile, safety, modulation of multiple neurotransmitter systems, and ability to produce neuroplastic changes make it a subject of study with implications for a wide range of neuropsychiatric disorders beyond its traditional use as an anesthetic agent. This article aims to provide an overview of the pharmacology of ketamine and briefly discuss its emerging use...
Addiction Research & Theory
March 31, 2025
Julian Ungar-Sargon
This paper examines the theological and existential tensions embedded in “Step 2” of the Alcoholics Anonymous 12- Step program within a clinical framework, particularly exploring the neurobiological, psychological, and spiritual dimensions of recovery from trauma, addiction, and chronic pain. Drawing on a multidisciplinary approach that integrates evidence from addiction medicine, Jungian...
Psychosomatic Medicine and General Practice
March 31, 2025
V. Rusanov
Introduction. Burnout syndrome (BS) is one of the most pressing challenges in modern medicine, especially in the context of the war in Ukraine, where the burden on the healthcare system has significantly increased. This condition not only deteriorates mental and physical health, reducing the quality of life for both patients and medical professionals, but also induces additional stress in...
International Research Journal of Ayurveda & Yoga
March 31, 2025
Selvaraj Giridharan, Bhuvana Pandiyan
Background: Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuroplasticity and cognition. Meditation and mind-body exercises such as yoga may increase BDNF levels, offering a non-pharmacological strategy to enhance brain health. Methods: This narrative review synthesizes evidence from published studies, primarily randomized controlled trials, sourced from PubMed, Scopus,...
March 31, 2025
Ryan J. Keenan, Rezaul Haque, Xianbo Jin et al.
preprint
Abstract Prolonged obesity induces enduring structural changes within neural circuits that contribute to maintaining the body at an elevated/obese body weight. These circuits regulate various mechanisms which can inhibit extreme or persistent weight loss. Therefore, a potential therapeutic strategy to facilitate weight loss is to promote structural plasticity within the brain. Psychedelic...
Neurology
March 30, 2025
Julian Ungar-Sargon
This article examines the question of whether living beings possess an innate, unchangeable nature or have the capacity for fundamental transformation a question with profound implications for treating addiction-related physical illness. By integrating diverse perspectives from religious and philosophical traditions, mystical thought, modern neuroscience, genetics, and clinical approaches to...
Scientific Reports
March 27, 2025
Juliana Yordanova, Valentina Nicolardi, Peter Malinowski et al.
4 citations
The experience of pain is a combined product of bottom-up and top-down influences mediated by attentional and emotional factors. Meditation states and traits are characterized by enhanced attention/emotion regulation and expanded self-awareness that can be expected to modify pain processing. The main objective of the present study was to explore the effects of long-term meditation on neural...