Psylocybina to psychoaktywny związek chemiczny występujący w grzybach z rodzaju Psilocybe, które zyskały znaczną popularność w ostatniej dekadzie ze względu na ich wpływ na neuroplastyczność, działanie serotoninergiczne oraz zdolność do tworzenia nowych połączeń między obszarami, które komunikowały się wcześniej ze sobą. Celem niniejszego badania jest ocena potencjalnych zastosowań psylocybiny...
Irritable bowel syndrome (IBS) is prevalent and can be disabling. Many patients remain symptomatic despite behavioral and medical therapies. Psychedelic-assisted therapy (PAT), in which serotonergic agents like psilocybin are administered in a psychotherapeutic context, has shown promise for refractory psychiatric disorders, including major depressive disorder and post-traumatic stress...
Psilocybin, ketamine, and MDMA are psychoactive compounds that exert behavioral effects with distinguishable but also overlapping features. The growing interest in using these compounds as therapeutics necessitates preclinical assays that can accurately screen psychedelics and related analogs. We posit that a promising approach may be to measure drug action on markers of neural plasticity in...
Methamphetamine use disorder is a significant public health concern. No pharmacological treatment options currently exist for methamphetamine use disorder, and psychotherapy is only moderately effective. Preliminary evidence suggests that ketamine-assisted psychotherapy produces sustained improvements in substance use and mental health symptomatology. In addition to direct antidepressant...
Autism Spectrum Disorders (ASD) are complex neurodevelopmental conditions characterized by deficits in social interaction, communication, and repetitive behaviors. This viewpoint explores the potential mechanisms through which psychedelics such as lysergic acid diethylamide (LSD), psilocybin, and 3,4-methylenedioxymethamphetamine (MDMA) may positively influence pro-social behaviors, focusing on...
Abstract: The convergence of artificial intelligence (AI) and neuroengineering is redefining the future of human cognition, paving the way for brain uploading, memory transfer, and digital consciousness. This chapter explores the scientific and philosophical dimensions of AI-driven neural interfaces, high-resolution brain mapping, and whole-brain emulation (WBE), examining how AI enhances our...
NeuroscienceFebruary 6, 2025Carolina Echeverry, Mariana Pazos, Maximiliano Torres-Pérez et al.9 citations
Neurodegenerative diseases are a group of disorders characterized by progressive degeneration of discrete groups of neurons causing severe disability. The main risk factor is age, hence their incidence is rapidly increasing worldwide due to the rise in life expectancy. Although the causes of the disease are not identified in about 90% of the cases, in the last decades there has been great...
Abstract Repetitive mild head injuries incurred while playing organized sports, during car accidents and falls, or in active military service are a major health problem. These head injuries induce cognitive, motor, and behavioral deficits that can last for months and even years with an increased risk of dementia, Parkinson’s disease, and chronic traumatic encephalopathy. There is no approved...
Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of futility-induced passivity in larval zebrafish, reversing the "giving-up" response that normally occurs when swimming fails to cause forward movement. Whole-brain imaging revealed that ketamine hyperactivates the norepinephrine-astroglia circuit...
Abstract Background The stress response is a physiological event finely orchestrated by the brain and aimed at restoring the homeostasis lost in case of environmental changes perceived as dangerous for survival. Most subjects successfully activate an adaptive stress response however, when the exposure to stressful stimuli is prolonged over time or overwhelming, some individuals may fail in...